Zapata Juan M, Martínez-García Vanesa, Lefebvre Sophie
Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, California 92037, USA.
Adv Exp Med Biol. 2007;597:1-24. doi: 10.1007/978-0-387-70630-6_1.
The TNF-receptor associated factor (TRAF) domain (TD), also known as the meprin and TRAF-C homology (MATH) domain is a fold of seven anti-parallel p-helices that participates in protein-protein interactions. This fold is broadly represented among eukaryotes, where it is found associated with a discrete set of protein-domains. Virtually all protein families encompassing a TRAF/MATH domain seem to be involved in the regulation of protein processing and ubiquitination, strongly suggesting a parallel evolution of the TRAF/MATH domain and certain proteolysis pathways in eukaryotes. The restricted number of living organisms for which we have information of their genetic and protein make-up limits the scope and analysis of the MATH domain in evolution. However, the available information allows us to get a glimpse on the origins, distribution and evolution of the TRAF/MATH domain, which will be overviewed in this chapter.
肿瘤坏死因子受体相关因子（TRAF）结构域（TD），也被称为膜金属蛋白酶和TRAF-C同源（MATH）结构域，是由七个反平行β-螺旋组成的折叠结构，参与蛋白质-蛋白质相互作用。这种折叠结构在真核生物中广泛存在，与一组离散的蛋白质结构域相关联。几乎所有包含TRAF/MATH结构域的蛋白质家族似乎都参与蛋白质加工和泛素化的调节，这强烈表明TRAF/MATH结构域与真核生物中某些蛋白水解途径存在平行进化关系。由于我们掌握其遗传和蛋白质组成信息的生物种类有限，限制了对MATH结构域进化的范围和分析。然而，现有信息使我们能够初步了解TRAF/MATH结构域的起源、分布和进化，本章将对此进行概述。
