Au Ping-Yee Billie, Yeh Wen-Chen
Campbell Family for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toranto, Ontario, Canada.
Adv Exp Med Biol. 2007;597:32-47. doi: 10.1007/978-0-387-70630-6_3.
RAF2 and TRAF5 are closely related members of the TRAF family of proteins. They are important signal transducers for a wide range of TNF receptor superfamily members, including TNFR1, TNFR2, CD40 and other lymphocyte costimulatory receptors, RANK/TRANCE-R, EDAR, LTbetaR, LMP-1 and IRE1. TRAF2 andTRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-kappaB activation, and MAPK and JNK activation. TRAF2 is heavily regulated by ubiquitin signals, and many of the signaling functions of TRAF2 are mediated through its RING domain and likely its own role as an E3 ubiquitin ligase.
RAF2和TRAF5是TRAF蛋白家族中关系密切的成员。它们是多种肿瘤坏死因子受体超家族成员的重要信号转导分子，这些成员包括TNFR1、TNFR2、CD40以及其他淋巴细胞共刺激受体、RANK/TRANCE-R、EDAR、LTβR、LMP-1和IRE1。因此，TRAF2和TRAF5调节多种生理功能，范围从T细胞和B细胞信号传导、炎症反应到器官发生和细胞存活。TRAF2和TRAF5介导的主要途径是NF-κB激活的经典途径和替代途径，以及MAPK和JNK激活。TRAF2受到泛素信号的严格调控，TRAF2的许多信号功能是通过其RING结构域介导的，可能还与其自身作为E3泛素连接酶的作用有关。
