肿瘤坏死因子受体相关因子6（TRAF6）的特征与生物学功能
Characteristics and biological functions of TRAF6.
作者信息
Inoue Jun-ichiro, Gohda Jin, Akiyama Taishin
机构信息
Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
出版信息
Adv Exp Med Biol. 2007;597:72-9. doi: 10.1007/978-0-387-70630-6_6.
TRAF6 is divergent from other members of the TRAF family. Therefore, TRAF6 was expected to play physiological roles distinct from those of other TRAFs. In this chapter, we focused on the physiological functions specific to TRAF6 but not other TRAFs in immune system, formation of skin appendices, and nervous system development by describing abnormal phenotypes observed in TRAF6-deficient mice. The role of TRAF6 in osteoclastogenesis and the molecular mechanisms ofTRAF6-mediated signal transduction are described in other chapters.
TRAF6与TRAF家族的其他成员不同。因此，预计TRAF6发挥的生理作用与其他TRAFs不同。在本章中，我们通过描述在TRAF6缺陷小鼠中观察到的异常表型，重点关注TRAF6特有的生理功能，而非其他TRAFs在免疫系统、皮肤附属器形成和神经系统发育中的功能。TRAF6在破骨细胞生成中的作用以及TRAF6介导的信号转导的分子机制在其他章节中描述。
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