Inoue Yuki, Inagaki Masumi, Gunji Atsuko, Kokubo Naomi, Kaga Makiko
Department of Developmental Disorder, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo.
No To Hattatsu. 2007 Jul;39(4):263-7.
The present study was organized to evaluate the cerebral inhibitory function in children with developmental disorders such as attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorder (PDD). Target and non-target-P300 event related potential (ERP) in response to stimuli of a visual oddball paradigm was analyzed. Ten children with AD/HD, 10 children with PDD and 10 healthy children were included in the study participants. Target-P300 component was observed in all subjects, which showed predominant amplitudes in Pz electrode. No significant differences were observed in amplitude and latency of target-P300 among three groups. In healthy children, Non-target-P300 component was observed mainly in Cz and Pz electrodes, while children with AD/HD had significantly reduced amplitudes of the component at Cz and children with PDD showed shorter latency at Oz. These results suggest that Non-target-P300 component in visual oddball paradigm possibly reflects the brain function associated with inhibitory processing and there is a relationship between the non-target-P300 potential abnormality and the AD/HD behavior.
本研究旨在评估患有发育障碍（如注意力缺陷多动障碍（AD/HD）和广泛性发育障碍（PDD））的儿童的大脑抑制功能。分析了视觉Oddball范式刺激下的靶标和非靶标P300事件相关电位（ERP）。研究参与者包括10名AD/HD儿童、10名PDD儿童和10名健康儿童。所有受试者均观察到靶标P300成分，其在Pz电极处显示出主要振幅。三组之间靶标P300的振幅和潜伏期无显著差异。在健康儿童中，非靶标P300成分主要在Cz和Pz电极处观察到，而AD/HD儿童在Cz处该成分的振幅显著降低，PDD儿童在Oz处的潜伏期较短。这些结果表明，视觉Oddball范式中的非靶标P300成分可能反映了与抑制处理相关的脑功能，并且非靶标P300电位异常与AD/HD行为之间存在关联。
