Oki Kenji, Yamane Kiminori, Kamei Nozomu, Nojima Hideki, Kohno Nobuoki
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Clin Endocrinol (Oxf). 2007 Nov;67(5):796-800. doi: 10.1111/j.1365-2265.2007.02966.x. Epub 2007 Jul 18.
Recent studies, both in vitro and in vivo, have indicated that visfatin is one of the inflammatory cytokines, although the relationship between visfatin and insulin resistance remains inconclusive. Accordingly, we assessed the association between visfatin concentrations in serum and those of interleukin-6 (IL-6) and C-reactive protein (CRP), known as markers of systemic inflammation, and also investigated the relationship between these serum concentrations and insulin resistance.
A total of 295 Japanese Americans living in Hawaii (126 men and 169 women, mean age 68.7 +/- 14.9 years) were enrolled. The serum levels of visfatin, IL-6 and CRP levels were measured, and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated as a marker of insulin resistance.
Significant positive correlations were found between serum levels of visfatin and IL-6 or CRP (r = 0.271, P < 0.001; r = 0.118, P < 0.05, respectively). Multiple regression analysis revealed that correlations between serum levels of visfatin and IL-6 or CRP remained significant after adjustments for age, sex, body mass index, per cent body fat and waist girth. There was no significant trend of the HOMA-IR for the tertiles of serum concentrations of visfatin. On the other hand, a significant trend towards increase of HOMA-IR with increasing tertile of serum concentrations, from the lowest to the highest, was observed for both IL-6 and CRP. The HOMA-IR in subjects with serum concentration of IL-6 or CRP in the highest or intermediate tertiles of IL-6 or CRP were significantly higher than that in subjects in the lowest tertile, even after adjustment for age and sex (IL-6: P < 0.001 and P < 0.001, respectively; CRP: P < 0.001 and P < 0.01, respectively).
Serum visfatin levels were positively correlated with the serum levels of IL-6 and slightly related with serum levels of CRP, but not with HOMA-IR, in Japanese Americans. Our results indicate that circulating visfatin may reflect inflammation status.
近期的体内外研究表明，内脂素是炎性细胞因子之一，尽管内脂素与胰岛素抵抗之间的关系尚无定论。因此，我们评估了血清中内脂素浓度与作为全身炎症标志物的白细胞介素-6（IL-6）和C反应蛋白（CRP）浓度之间的关联，并研究了这些血清浓度与胰岛素抵抗之间的关系。
共纳入295名居住在夏威夷的日裔美国人（126名男性和169名女性，平均年龄68.7±14.9岁）。测量了内脂素、IL-6和CRP的血清水平，并计算了胰岛素抵抗的稳态模型评估（HOMA-IR）作为胰岛素抵抗的标志物。
血清内脂素水平与IL-6或CRP之间存在显著正相关（r = 0.271，P < 0.001；r = 0.118，P < 0.05）。多元回归分析显示，在调整年龄、性别、体重指数、体脂百分比和腰围后，血清内脂素水平与IL-6或CRP之间的相关性仍然显著。内脂素血清浓度三分位数的HOMA-IR无显著趋势。另一方面，对于IL-6和CRP，观察到随着血清浓度三分位数从最低到最高增加，HOMA-IR有显著增加趋势。即使在调整年龄和性别后，IL-6或CRP血清浓度处于最高或中间三分位数的受试者的HOMA-IR仍显著高于最低三分位数的受试者（IL-6：分别为P < 0.001和P < 0.001；CRP：分别为P < 0.001和P < 0.01）。
在日裔美国人中，血清内脂素水平与IL-6血清水平呈正相关，与CRP血清水平轻度相关，但与HOMA-IR无关。我们的结果表明，循环内脂素可能反映炎症状态。
