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本文引用的文献

1
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.与DNA结合的CSL-Notch-Mastermind三元复合物的晶体结构。
Cell. 2006 Mar 10;124(5):985-96. doi: 10.1016/j.cell.2006.01.035.
2
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.MAML共激活因子募集至Notch转录复合物过程中协同作用的结构基础。
Cell. 2006 Mar 10;124(5):973-83. doi: 10.1016/j.cell.2005.12.037.
3
Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.Nipped-A是果蝇SAGA和Tip60复合物中的Tra1/TRRAP亚基，在翅发育过程中的Notch信号传导中具有多种作用。
Mol Cell Biol. 2006 Mar;26(6):2347-59. doi: 10.1128/MCB.26.6.2347-2359.2006.
4
Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.无毛蛋白介导的Notch靶基因抑制需要Gro和CtBP共抑制因子的联合活性。
Mol Cell Biol. 2005 Dec;25(23):10433-41. doi: 10.1128/MCB.25.23.10433-10441.2005.
5
Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster.对无毛功能获得性表型进行的遗传修饰筛选揭示了黑腹果蝇中参与细胞分化、细胞生长和细胞凋亡的基因。
Genetics. 2005 Nov;171(3):1137-52. doi: 10.1534/genetics.105.044453. Epub 2005 Aug 22.
6
Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.人类SRCAP和果蝇DOM是在Notch信号通路中发挥作用的同源物。
Mol Cell Biol. 2005 Aug;25(15):6559-69. doi: 10.1128/MCB.25.15.6559-6569.2005.
7
DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.DREF是果蝇成虫盘高效生长和细胞周期进程所必需的。
Mol Cell Biol. 2005 Jul;25(13):5590-8. doi: 10.1128/MCB.25.13.5590-5598.2005.
8
Identification of genetic loci that interact with cut during Drosophila wing-margin development.果蝇翅缘发育过程中与切割相互作用的基因座的鉴定。
Genetics. 2005 Aug;170(4):1775-95. doi: 10.1534/genetics.105.043125. Epub 2005 Jun 14.
9
Cell-cycle control during development: taking it up a notch.发育过程中的细胞周期调控：提升一个档次。
Dev Cell. 2005 Apr;8(4):451-2. doi: 10.1016/j.devcel.2005.03.013.
10
Bre1 is required for Notch signaling and histone modification.Notch信号传导和组蛋白修饰需要Bre1。
Dev Cell. 2005 Feb;8(2):279-86. doi: 10.1016/j.devcel.2004.11.020.

在果蝇中，putzig是细胞增殖所必需的，并且调节Notch活性。

putzig is required for cell proliferation and regulates notch activity in Drosophila.

作者信息

Kugler Sabrina J, Nagel Anja C

机构信息

Institute of Genetics (240), University of Hohenheim, 70599 Stuttgart, Germany.

出版信息

Mol Biol Cell. 2007 Oct;18(10):3733-40. doi: 10.1091/mbc.e07-03-0263. Epub 2007 Jul 18.

DOI:10.1091/mbc.e07-03-0263
PMID:17634285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1995712/
Abstract

We have identified the gene putzig (pzg) as a key regulator of cell proliferation and of Notch signaling in Drosophila. pzg encodes a Zn-finger protein that was found earlier within a macromolecular complex, including TATA-binding protein-related factor 2 (TRF2)/DNA replication-related element factor (DREF). This complex is involved in core promoter selection, where DREF functions as a transcriptional activator of replication-related genes. Here, we provide the first in vivo evidence that pzg is required for the expression of cell cycle and replication-related genes, and hence for normal developmental growth. Independent of its role in the TRF2/DREF complex, pzg acts as a positive regulator of Notch signaling that may occur by chromatin activation. Down-regulation of pzg activity inhibits Notch target gene activation, whereas Hedgehog (Hh) signal transduction and growth regulation are unaffected. Our findings uncover different modes of operation of pzg during imaginal development of Drosophila, and they provide a novel mechanism of Notch regulation.

摘要

我们已确定果蝇中的putzig（pzg）基因是细胞增殖和Notch信号传导的关键调节因子。pzg编码一种锌指蛋白，该蛋白先前在一个大分子复合物中被发现，该复合物包括TATA结合蛋白相关因子2（TRF2）/DNA复制相关元件因子（DREF）。这个复合物参与核心启动子的选择，其中DREF作为复制相关基因的转录激活因子发挥作用。在这里，我们提供了首个体内证据，表明pzg是细胞周期和复制相关基因表达所必需的，因此对于正常的发育生长也是必需的。独立于其在TRF2/DREF复合物中的作用，pzg作为Notch信号传导的正调节因子，可能通过染色质激活而发生。pzg活性的下调会抑制Notch靶基因的激活，而Hedgehog（Hh）信号转导和生长调节不受影响。我们的研究结果揭示了pzg在果蝇成虫发育过程中的不同作用模式，并提供了一种新的Notch调节机制。