O'Rourke Ann P, Lazebnik Mariya, Bertram John M, Converse Mark C, Hagness Susan C, Webster John G, Mahvi David M
Department of Surgery, University of Wisconsin, Madison, WI 53792, USA.
Phys Med Biol. 2007 Aug 7;52(15):4707-19. doi: 10.1088/0031-9155/52/15/022. Epub 2007 Jul 18.
Hepatic malignancies have historically been treated with surgical resection. Due to the shortcomings of this technique, there is interest in other, less invasive, treatment modalities, such as microwave hepatic ablation. Crucial to the development of this technique is the accurate knowledge of the dielectric properties of human liver tissue at microwave frequencies. To this end, we characterized the dielectric properties of in vivo and ex vivo normal, malignant and cirrhotic human liver tissues from 0.5 to 20 GHz. Analysis of our data at 915 MHz and 2.45 GHz indicates that the dielectric properties of ex vivo malignant liver tissue are 19 to 30% higher than normal tissue. The differences in the dielectric properties of in vivo malignant and normal liver tissue are not statistically significant (with the exception of effective conductivity at 915 MHz, where malignant tissue properties are 16% higher than normal). Also, the dielectric properties of in vivo normal liver tissue at 915 MHz and 2.45 GHz are 16 to 43% higher than ex vivo. No statistically significant differences were found between the dielectric properties of in vivo and ex vivo malignant tissue (with the exception of effective conductivity at 915 MHz, where malignant tissue properties are 28% higher than normal). We report the one-pole Cole-Cole parameters for ex vivo normal, malignant and cirrhotic liver tissue in this frequency range. We observe that wideband dielectric properties of in vivo liver tissue are different from the wideband dielectric properties of ex vivo liver tissue, and that the in vivo data cannot be represented in terms of a Cole-Cole model. Further work is needed to uncover the mechanisms responsible for the observed wideband trends in the in vivo liver data.
肝恶性肿瘤在历史上一直采用手术切除治疗。由于这种技术存在缺陷,人们对其他侵入性较小的治疗方式产生了兴趣,比如微波肝脏消融术。该技术发展的关键在于准确了解微波频率下人体肝脏组织的介电特性。为此,我们对体内和体外的正常、恶性及肝硬化人体肝脏组织在0.5至20吉赫兹的介电特性进行了表征。对我们在915兆赫兹和2.45吉赫兹的数据进行分析表明,体外恶性肝脏组织的介电特性比正常组织高19%至30%。体内恶性和正常肝脏组织的介电特性差异无统计学意义(915兆赫兹处的有效电导率除外,恶性组织特性比正常组织高16%)。此外,915兆赫兹和2.45吉赫兹时体内正常肝脏组织的介电特性比体外高16%至43%。体内和体外恶性组织的介电特性之间未发现统计学上的显著差异(915兆赫兹处的有效电导率除外,恶性组织特性比正常组织高28%)。我们报告了该频率范围内体外正常、恶性和肝硬化肝脏组织的单极科尔 - 科尔参数。我们观察到体内肝脏组织的宽带介电特性与体外肝脏组织的宽带介电特性不同,并且体内数据无法用科尔 - 科尔模型表示。需要进一步开展工作来揭示导致体内肝脏数据中观察到的宽带趋势的机制。