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即使是低强度和小运动量的运动训练也可能改善老年人的胰岛素抵抗。

Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.

作者信息

Kodama Satoru, Shu Miao, Saito Kazumi, Murakami Haruka, Tanaka Kiyoji, Kuno Shinya, Ajisaka Ryuichi, Sone Yasuko, Onitake Fumiko, Takahashi Akimitsu, Shimano Hitoshi, Kondo Kazuo, Yamada Nobuhiro, Sone Hirohito

机构信息

Department of Internal Medicine, University of Tsukuba.

出版信息

Intern Med. 2007;46(14):1071-7. doi: 10.2169/internalmedicine.46.0096. Epub 2007 Jul 17.

Abstract

OBJECTIVE

Moderate to high intensity exercise training is known to ameliorate the coronary risk factors in relation to an improvement in body composition. However, the benefit of low-intensity and low-volume training for these risk factors remains unclear in elderly people. Therefore, we investigated the effects of low-intensity and low-volume exercise training on blood lipid values and insulin resistance in the elderly.

METHODS

A total of 56 healthy elderly individuals (42 females and 14 males) aged 64+/-6 years participated in a 12-week exercise program, comprising aerobic training and resistance training.

RESULTS

After the program, there were no significant changes in high-density lipoprotein cholesterol, triglyceride serum levels, or in peak oxygen uptake on average. However, the homeostasis of minimal assessment of insulin resistance (HOMA-IR) value was significantly reduced by 21%. The participants were categorized into tertiles based on initial Body Mass Index (BMI). The Middle-BMI group (non-obese subjects) showed reduced HOMA-IR (2.0-->1.3, P<0.01), but this reduction was not associated with the reduction in BMI (r=0.08, P=0.74), whereas the two reductions were significantly associated in the High-BMI group (r=0.61, P=0.01).

CONCLUSION

Even low-intensity and low-volume exercise training, which would ordinarily be insufficient for improving mean lipid values or aerobic fitness, was found to be effective in improving insulin resistance in the elderly. The improvement in insulin resistance was independent of the improvement in obesity.

摘要

目的

众所周知,中高强度运动训练可改善与身体成分改善相关的冠状动脉危险因素。然而,低强度、低运动量训练对这些危险因素的益处,在老年人中仍不明确。因此,我们研究了低强度、低运动量运动训练对老年人血脂值和胰岛素抵抗的影响。

方法

共有56名年龄在64±6岁的健康老年人(42名女性和14名男性)参加了一项为期12周的运动计划,该计划包括有氧运动训练和抗阻训练。

结果

该计划结束后,高密度脂蛋白胆固醇、甘油三酯血清水平或平均峰值摄氧量均无显著变化。然而,胰岛素抵抗最小评估的稳态模型评估(HOMA-IR)值显著降低了21%。参与者根据初始体重指数(BMI)分为三分位数。中等BMI组(非肥胖受试者)的HOMA-IR降低(2.0→1.3,P<0.01),但这种降低与BMI的降低无关(r=0.08,P=0.74),而在高BMI组中,这两种降低显著相关(r=0.61,P=0.01)。

结论

即使是通常不足以改善平均血脂值或有氧适能的低强度、低运动量运动训练,也被发现对改善老年人的胰岛素抵抗有效。胰岛素抵抗的改善与肥胖的改善无关。

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