Ito Eiichi, Okamoto Hiroshi, Mochizuki Atsuko, Ohara Kuniko, Kato Maiko, Terashima Yutaka, Tanaka Eiichi, Takagi Kae, Uchiyama Shinichiro, Iwata Makoto
Department of Neurology, Neurological Institute, Tokyo Women's Medical University.
Intern Med. 2007;46(14):1139-42. doi: 10.2169/internalmedicine.46.0029. Epub 2007 Jul 17.
We encountered two cases of RS3PE (remitting seronegative symmetrical synovitis with pitting edema) syndrome accompanied by Parkinson's disease (PD). Although the etiology of RS3PE syndrome is still unknown, several possible associations, such as malignancies and viral infections, have been reported; RS3PE syndrome is thought to be an autoimmune-mediated disorder. The present patients did not have any factors which are reported to be associated with RS3PE. Whether or not the complication of PD and RS3PE syndrome is incidental needs to be further examined, and we discuss here the possible cause of association between PD and RS3PE syndrome, including dopamine agonists one of the anti-PD medications.
我们遇到了两例伴有帕金森病（PD）的缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）综合征病例。虽然RS3PE综合征的病因仍不清楚，但已报道了一些可能的关联，如恶性肿瘤和病毒感染；RS3PE综合征被认为是一种自身免疫介导的疾病。目前的患者没有任何据报道与RS3PE相关的因素。PD与RS3PE综合征的并发是否偶然需要进一步研究，我们在此讨论PD与RS3PE综合征之间可能的关联原因，包括抗PD药物之一的多巴胺激动剂。
