Khait L, Birla Ravi K
The University of Michigan, Section of Cardiac Surgery, Ann Arbor, MI 48109, USA.
Regen Med. 2007 Jul;2(4):391-406. doi: 10.2217/17460751.2.4.391.
Mortalities resulting from cardiovascular disorders remain high, with an urgent need to develop novel treatment modalities. Tissue-engineering therapies aim to provide cell-based alternatives to conventional options. Significant technological advancements have occurred during the last decade towards the fabrication of functional 3D heart muscle in vitro. More recent research has focused on the development of cell-based cardiac pumps and tissue-engineered ventricles. The global objective of this collective work is to simulate the functional performance of the left ventricle, utilizing completely cell-based options. Current prototypes have shown several physiological performance metrics, including the ability of these devices to generate intraluminal pressure upon electrical stimulation. This review will highlight the transition from tissue engineering 3D heart muscle to cell-based cardiac pumps/ventricles.
心血管疾病导致的死亡率仍然很高，迫切需要开发新的治疗方法。组织工程疗法旨在提供基于细胞的传统治疗替代方案。在过去十年中，在体外制造功能性三维心肌方面取得了重大技术进步。最近的研究集中在基于细胞的心脏泵和组织工程心室的开发上。这项集体工作的总体目标是利用完全基于细胞的方法模拟左心室的功能性能。目前的原型已经展示了几个生理性能指标，包括这些装置在电刺激下产生腔内压力的能力。本综述将重点介绍从组织工程三维心肌到基于细胞的心脏泵/心室的转变。
