Hecker Louise, Birla Ravi K
Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.
Regen Med. 2007 Mar;2(2):125-44. doi: 10.2217/17460751.2.2.125.
According to the National Transplant Society, more than 7000 Americans in need of organs die every year owing to a lack of lifesaving organs. Bioengineering 3D organs in vitro for subsequent implantation may provide a solution to this problem. The field of tissue engineering in its most rudimentary form is focused on the developed of transplantable organ substitutes in the laboratory. The objective of this article is to introduce important technological hurdles in the field of cardiac tissue engineering. This review starts with an overview of tissue engineering, followed by an introduction to the field of cardiovascular tissue engineering and finally summarizes some of the key advances in cardiac tissue engineering; specific topics discussed in this article include cell sourcing and biomaterials, in vitro models of cardiac muscle and bioreactors. The article concludes with thoughts on the utility of tissue-engineering models in basic research as well as critical technological hurdles that need to be addressed in the future.
根据国家移植协会的数据，每年有超过7000名需要器官移植的美国人因缺乏救命器官而死亡。在体外生物工程制造3D器官以供后续植入可能为这个问题提供解决方案。组织工程领域最基本的形式专注于在实验室中开发可移植的器官替代品。本文的目的是介绍心脏组织工程领域的重要技术障碍。这篇综述首先概述组织工程，接着介绍心血管组织工程领域，最后总结心脏组织工程的一些关键进展；本文讨论的具体主题包括细胞来源和生物材料、心肌的体外模型以及生物反应器。文章最后思考了组织工程模型在基础研究中的效用以及未来需要解决的关键技术障碍。
