Järver P, Langel K, El-Andaloussi S, Langel U
Laboratory of Molecular Biotechnology, Institute of Technology, Tartu University, Tartu, Estonia.
Biochem Soc Trans. 2007 Aug;35(Pt 4):770-4. doi: 10.1042/BST0350770.
CPPs (cell-penetrating peptides) can be defined as short peptides that are able to efficiently penetrate cellular lipid bilayers. Because of this remarkable feature, they are excellent candidates regarding alterations in gene expression. CPPs have been utilized in in vivo and in vitro experiments as delivery vectors for different bioactive cargoes. This review focuses on the experiments performed in recent years where CPPs have been used as vectors for multiple effectors of gene expression such as oligonucleotides for antisense, siRNA (small interfering RNA) and decoy dsDNA (double-stranded DNA) applications, and as transfection agents for plasmid delivery.
细胞穿透肽（CPPs）可定义为能够有效穿透细胞脂质双层的短肽。由于这一显著特性，它们在基因表达改变方面是极佳的候选物。CPPs已在体内和体外实验中用作不同生物活性物质的递送载体。本综述聚焦于近年来进行的实验，其中CPPs被用作基因表达多种效应物的载体，如用于反义寡核苷酸、小干扰RNA（siRNA）和诱饵双链DNA（dsDNA）应用，以及用作质粒递送的转染剂。
