Lupattelli G, Marchesi S, Ronti T, Lombardini R, Bruscoli S, Bianchini R, Vaudo G, Riccardi C, Mannarino E
Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
J Clin Pharm Ther. 2007 Aug;32(4):373-9. doi: 10.1111/j.1365-2710.2007.00832.x.
Resistin could be the linkage between the adipose tissue and the insulin resistance. In humans, the role of resistin on metabolic and vascular homeostasis is not well defined. The aim of this study was to investigate the possible association between resistin expression and insulin resistance.
We evaluated the relationship between monocyte expression of mRNA and anthropometric and metabolic parameters of insulin resistance. We focused on the potential role of resistin on endothelial function. Thirty-nine patients with metabolic syndrome (MS) and clinically free from cardiovascular disease, and 15 healthy subjects were included in this study. All subjects underwent clinical examination, assessment of haematochemical parameters, bioimpedentiometry, measurement of monocyte resistin mRNA and of brachial-artery flow-mediated vasodilation (FMV). Patients with MS showed higher levels of interleukin-6 (IL; 2.1 +/- 1.2 vs. 1.2 +/- 0.9 pg/mL, P < 0.05) and reduced FMV (5.4 +/- 3.9 vs. 8.3 +/- 3.1%, P < 0.05). The subjects were divided into two groups: (i) subjects with high expression mRNA resistin levels and (ii) subjects with low or not detectable; Group 1 was younger (50 +/- 13 vs. 59 +/- 11 years, P = 0.01), showed higher IL-6 values (2.3 +/- 1.2 vs. 1.6 +/- 1.2, P = 0.03) and lower values of FMV (4.3 +/- 2.8 vs. 7.4 +/- 3.9%, P = 0.003). With univariate analysis monocyte mRNA showed a significant positive correlation with waist circumference (r = 0.27, P < 0.05) and IL-6 (r = 0.26, P < 0.05) and a negative correlation with FMV (r = -0.38, P < 0.005). With multivariate regression analysis brachial-artery diameter, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, IL-6 and RNAm resistin expression were independent predictors of reduced FMV.
mRNA resistin negatively influences FMV, and is a possible in vivo index of endothelial dysfunction.
抵抗素可能是脂肪组织与胰岛素抵抗之间的联系纽带。在人类中，抵抗素对代谢和血管稳态的作用尚未明确界定。本研究旨在探讨抵抗素表达与胰岛素抵抗之间可能存在的关联。
我们评估了单核细胞mRNA表达与胰岛素抵抗的人体测量学和代谢参数之间的关系。我们重点关注抵抗素对内皮功能的潜在作用。本研究纳入了39例代谢综合征（MS）患者且临床上无心血管疾病，以及15名健康受试者。所有受试者均接受了临床检查、血液生化参数评估、生物电阻抗测量、单核细胞抵抗素mRNA测量以及肱动脉血流介导的血管舒张（FMV）测量。MS患者的白细胞介素-6（IL）水平较高（2.1±1.2 vs. 1.2±0.9 pg/mL，P<0.05），且FMV降低（5.4±3.9 vs. 8.3±3.1%，P<0.05）。受试者被分为两组：（i）抵抗素mRNA水平高表达的受试者和（ii）抵抗素mRNA水平低表达或未检测到的受试者；第1组更年轻（50±13 vs. 59±11岁，P = 0.01），IL-6值更高（2.3±1.2 vs. 1.6±1.2，P = 0.03），FMV值更低（4.3±2.8 vs. 7.4±3.9%，P = 0.003）。单因素分析显示，单核细胞mRNA与腰围（r = 0.27，P<0.05）和IL-6（r = 0.26，P<0.05）呈显著正相关，与FMV呈负相关（r = -0.38，P<0.005）。多因素回归分析显示，肱动脉直径、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、IL-6和抵抗素mRNA表达是FMV降低的独立预测因素。
抵抗素mRNA对FMV有负面影响，并且可能是内皮功能障碍的一种体内指标。
