Marchesi S, Vaudo G, Lupattelli G, Lombardini R, Roscini A R, Brozzetti M, Siepi D, Mannarino E
Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Perugia, Italy.
J Clin Pharm Ther. 2007 Oct;32(5):477-82. doi: 10.1111/j.1365-2710.2007.00856.x.
Adipose tissue is not an inert deposit of fat; in the truncal area, it seems to be metabolically active, due to the adipokines produced locally. These substances are related to insulin resistance, inflammation and atherosclerotic damage to the vascular system. The development of ultrasound methodologies enable better estimation of fat distribution and more detailed investigation of the metabolic aspects of the fat depots and their impact on the initial stages of atherosclerosis.
To investigate the influence of abdominal fat on endothelial function, the initial stages of atherosclerotic vascular damage and its relationship with inflammatory status in normal-overweight subjects [n. 162, body mass index (BMI) >25 kg/m(2) to <30 kg/m(2)].
A total of 162 Caucasian postmenopausal women (mean age 54 +/- 4 years, menopausal age 8 +/- 4 years) were subdivided on the basis of the median value of the visceral fat distribution and associations with brachial flow-mediated vasoactivity (FMV), BMI, intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), total and LDL cholesterol investigated.
Subjects with lower levels of visceral fat had a higher brachial FMV (7.9 +/- 4.3 vs. 5.1 +/- 3.2%, P < 0.05) and lower BMI, waist, sICAM-1, sVCAM-1, total and LDL cholesterol. In univariate analyses, abdominal visceral fat showed a direct correlation with sICAM-1 (r = 0.43, P < 0.001), and an inverse correlation with FMV (r = -0.49, P < 0.01). Moreover an indirect relationship emerged between brachial FMV and sICAM-levels (r = -0.36, P < 0.05). In a multivariate analysis the predictive variables for brachial FMV were LDL cholesterol (beta = -0.22, P < 0.05), visceral fat (beta = -0.32, P < 0.05), sICAM-1 (beta = -0.18, P < 0.05), HDL cholesterol (beta = 0.25, P < 0.05) and brachial diameter (beta = -0.27, P < 0.05). Subcutaneous fat and triglycerides were also included in the model.
In Caucasian normal-overweight women, visceral fat thickness was directly associated with the level of soluble ICAM-1 and inversely with FMV, thereby showing its relevance to endothelial function and the inflammatory state.
脂肪组织并非脂肪的惰性沉积；在躯干区域，由于局部产生的脂肪因子，它似乎具有代谢活性。这些物质与胰岛素抵抗、炎症以及血管系统的动脉粥样硬化损伤有关。超声方法的发展使得能够更好地估计脂肪分布，并更详细地研究脂肪储存库的代谢方面及其对动脉粥样硬化初始阶段的影响。
探讨腹部脂肪对正常超重受试者[162例，体重指数（BMI）>25kg/m²至<30kg/m²]内皮功能、动脉粥样硬化血管损伤初始阶段的影响及其与炎症状态的关系。
总共162名白种人绝经后女性（平均年龄54±4岁，绝经年龄8±4岁）根据内脏脂肪分布的中位数以及与肱动脉血流介导的血管活性（FMV）、BMI、细胞间粘附分子-1（sICAM-1）、血管细胞粘附分子-1（sVCAM-1）、总胆固醇和低密度脂蛋白胆固醇的相关性进行分组研究。
内脏脂肪水平较低的受试者肱动脉FMV较高（7.9±4.3对5.1±3.2%，P<0.05），且BMI、腰围、sICAM-1、sVCAM-1、总胆固醇和低密度脂蛋白胆固醇较低。在单变量分析中，腹部内脏脂肪与sICAM-1呈正相关（r=0.43，P<0.001），与FMV呈负相关（r=-0.49，P<0.01）。此外，肱动脉FMV与sICAM水平之间存在间接关系（r=-0.36，P<0.05）。在多变量分析中，肱动脉FMV的预测变量为低密度脂蛋白胆固醇（β=-0.22，P<0.05）、内脏脂肪（β=-0.32，P<0.05）、sICAM-1（β=-0.18，P<0.05）、高密度脂蛋白胆固醇（β=0.25，P<0.05）和肱动脉直径（β=-0.27，P<0.05）。皮下脂肪和甘油三酯也纳入了该模型。
在白种人正常超重女性中，内脏脂肪厚度与可溶性ICAM-1水平直接相关，与FMV呈负相关，从而表明其与内皮功能和炎症状态相关。
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