de Groot Mark C H, van Puijenbroek Eugène P
Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands.
Br J Clin Pharmacol. 2007 Oct;64(4):542-5. doi: 10.1111/j.1365-2125.2007.02908.x. Epub 2007 Jul 17.
Topical use of clindamycin has been associated with taste disorders in the literature, but little is known about the nature of this adverse drug reaction. The aim of this article was to describe reports of clindamycin-induced taste disorders and to analyse the factors involved.
The adverse drug reaction database of the Netherlands Pharmacovigilance Centre was searched for reports concerning taste disorders with antibiotics. Clinical review of the cases and statistical analysis with logistic regression were performed. Characteristics of patients who reported taste disorders were compared for age, gender and formulation in clindamycin vs. other antibiotic users.
Taste disorders were reported in seven (18%) of the clindamycin cases. In five reports an oral formulation was involved, in one report intravenous (i.v.) administration and in one report both formulations were used. Latency was <1 day after start and in one case taste disorders were present repeatedly at 10 min after every i.v. application. The adjusted reporting odds ratio was 7.0 (95% confidence interval 2.8, 17.3) and supports a possible causal relationship.
The association of clindamycin and taste disorders is supported by disproportionality analysis and seems to be independent of possible confounders such as age, gender and infections. The case reports suggest a role for clindamycin concentrations excreted in body fluids like saliva.
文献报道局部使用克林霉素与味觉障碍有关，但对于这种药物不良反应的本质知之甚少。本文旨在描述克林霉素所致味觉障碍的报告并分析相关因素。
检索荷兰药物警戒中心的药物不良反应数据库，查找有关抗生素引起味觉障碍的报告。对病例进行临床评估并采用逻辑回归进行统计分析。比较报告味觉障碍的患者在年龄、性别以及使用克林霉素与其他抗生素剂型方面的特征。
在克林霉素病例中有7例（18%）报告了味觉障碍。5份报告涉及口服剂型，1份报告为静脉注射，1份报告两种剂型均使用过。开始用药后潜伏期<1天，1例患者每次静脉注射后10分钟反复出现味觉障碍。调整后的报告比值比为7.0（95%置信区间2.8, 17.3），支持可能的因果关系。
比例分析支持克林霉素与味觉障碍之间的关联，且似乎独立于年龄、性别和感染等可能的混杂因素。病例报告提示唾液等体液中排泄的克林霉素浓度可能起作用。
