Clark Brychan M, Homeyer Diane C, Glass Kristen R, D'Avignon Laurie C
Department of Infectious Diseases, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas 78236, USA.
Pharmacotherapy. 2007 Sep;27(9):1343-6. doi: 10.1592/phco.27.9.1343.
Drug-induced acute febrile neutrophilic dermatosis, or Sweet's syndrome, is rare and, to our knowledge, has not previously been associated with clindamycin therapy. We describe a 47-year-old woman with type 2 diabetes mellitus and end-stage renal disease requiring hemodialysis who developed Sweet's syndrome after receiving oral and intravenous clindamycin for a tooth infection. After the clindamycin was discontinued, the patient's clinical symptoms resolved over several days. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship between the patient's development of Sweet's syndrome and clindamycin therapy. Clinicians should be aware that Sweet's syndrome can occur with clindamycin treatment. Early recognition of this condition in conjunction with cessation of drug exposure, with or without antiinflammatory therapy, can produce complete recovery.
药物性急性发热性嗜中性皮病，即斯威特综合征，较为罕见，据我们所知，此前尚未与克林霉素治疗相关联。我们报告一名47岁患有2型糖尿病和终末期肾病且需要血液透析的女性，其在因牙齿感染接受口服和静脉注射克林霉素后患上了斯威特综合征。停用克林霉素后，患者的临床症状在数天内得以缓解。使用纳兰霍药物不良反应概率量表表明，患者斯威特综合征的发生与克林霉素治疗之间可能存在关联。临床医生应意识到，使用克林霉素治疗时可能会发生斯威特综合征。早期识别这种情况并停止药物暴露，无论是否进行抗炎治疗，均可实现完全康复。
