Hynes R O
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
J Thromb Haemost. 2007 Jul;5 Suppl 1:32-40. doi: 10.1111/j.1538-7836.2007.02569.x.
Vascular development requires correct interactions among endothelial cells, pericytes and surrounding cells. These interactions involve many cell adhesion interactions, including cell-matrix interactions both with basement membranes and with surrounding extracellular matrices. Investigations of the contributions of these various interactions in vascular development and angiogenesis have been rather uneven and incomplete over the past 10-15 years. There has been considerable concentration on a few receptors, matrix proteins and proteolytic fragments with the goal of finding means to control angiogenesis. Many other potential contributors have received much less attention. Even for those molecules that have been subject to intensive investigation, our knowledge is incomplete. This review will survey the spectrum of extracellular matrix (ECM) proteins and cell-matrix adhesion receptors (particularly integrins) that are likely to contribute to angiogenesis and discuss what is known and not known about the roles of each of them.
血管发育需要内皮细胞、周细胞和周围细胞之间进行正确的相互作用。这些相互作用涉及许多细胞黏附相互作用，包括与基底膜以及周围细胞外基质的细胞-基质相互作用。在过去10至15年里，对这些不同相互作用在血管发育和血管生成中所起作用的研究相当不均衡且不完整。人们相当集中地关注了少数几种受体、基质蛋白和蛋白水解片段，目的是找到控制血管生成的方法。许多其他潜在的促成因素受到的关注则少得多。即使对于那些经过深入研究的分子，我们的了解也并不完整。本综述将概述可能对血管生成有贡献的细胞外基质（ECM）蛋白和细胞-基质黏附受体（特别是整合素）的范围，并讨论我们对它们各自作用的已知和未知情况。
