Cunha Filho J S, Terres L F, Holanda F, Freitas F, Glitz C, Genro V K, Arbo E
Ob/Gyn depto., Hospital de Clínicas de Porto Alegre, Programa de Pós-graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, Porto Alegre, RS, CEP 90035-003, Brazil.
J Assist Reprod Genet. 2007 Aug;24(8):326-30. doi: 10.1007/s10815-007-9125-x. Epub 2007 Jul 17.
The purpose of the study was to compare the effectiveness of GnRH antagonist with luteal phase estradiol administration to GnRH agonist cycles, long protocol.
55 IVF-ICSI patients received oestradiol in the luteal phase of the cycle, before a cycle with GnRH antagonist. Fifty-five patients submitted to IVF-ICSI with the use of agonist were allocated, age matched, as a control group (historical control). The primary outcome was the number of retrieved oocytes.
Patients were similar in terms of clinical characteristics. No differences were found in the number of oocytes retrieved (study group, 8.1 +/- 4.7; control group, 7.4 +/- 4.5) or in oocyte quality.
We clearly demonstrated that the effectiveness of GnRH antagonist when combined with luteal phase estradiol is comparable to GnRH agonist cycles.
本研究旨在比较促性腺激素释放激素（GnRH）拮抗剂联合黄体期雌二醇给药与GnRH激动剂长方案周期的有效性。
55例体外受精-卵胞浆内单精子注射（IVF-ICSI）患者在使用GnRH拮抗剂周期前的黄体期接受雌二醇治疗。55例接受激动剂进行IVF-ICSI的患者作为对照组（历史对照），年龄匹配。主要结局是获卵数。
两组患者的临床特征相似。在获卵数（研究组，8.1±4.7；对照组，7.4±4.5）或卵母细胞质量方面未发现差异。
我们明确证明，GnRH拮抗剂联合黄体期雌二醇的有效性与GnRH激动剂周期相当。
