树突状细胞肿瘤：概述

Dendritic cell neoplasms: an overview.

作者信息

Kairouz Sebastien, Hashash Jana, Kabbara Wadih, McHayleh Wassim, Tabbara Imad A

机构信息

Department of Internal Medicine, Division of Hematology/Oncology, The George Washington University Medical Center, Washington, DC 20037, USA.

出版信息

Am J Hematol. 2007 Oct;82(10):924-8. doi: 10.1002/ajh.20857.

DOI:10.1002/ajh.20857

PMID:17636477

Abstract

Dendritic cell neoplasms are rare tumors that are being recognized with increasing frequency. They were previously classified as lymphomas, sarcomas, or histiocytic neoplasms. The World Health Organization (WHO) classifies dendritic cell neoplasms into five groups: Langerhans' cell histiocytosis, Langerhans' cell sarcoma, Interdigitating dendritic cell sarcoma/tumor, Follicular dendritic cell sarcoma/tumor, and Dendritic cell sarcoma, not specified otherwise (Jaffe, World Health Organization classification of tumors 2001; 273-289). Recently, Pileri et al. provided a comprehensive immunohistochemical classification of histiocytic and dendritic cell tumors (Pileri et al., Histopathology 2002;59:161-167). In this article, a concise overview regarding the pathological, clinical, and therapeutic aspects of follicular dendritic, interdigitating dendritic, and Langerhans' cell tumors is presented.

摘要

树突状细胞肿瘤是一类罕见肿瘤，其发病率正日益增加。它们以前被归类为淋巴瘤、肉瘤或组织细胞肿瘤。世界卫生组织（WHO）将树突状细胞肿瘤分为五组：朗格汉斯细胞组织细胞增多症、朗格汉斯细胞肉瘤、交错突细胞肉瘤/肿瘤、滤泡树突状细胞肉瘤/肿瘤以及未另行规定的树突状细胞肉瘤（贾菲，《世界卫生组织肿瘤分类》2001年；273 - 289页）。最近，皮耶里等人对组织细胞和树突状细胞肿瘤进行了全面的免疫组织化学分类（皮耶里等人，《组织病理学》2002年；59:161 - 167）。本文对滤泡树突状细胞、交错突细胞和朗格汉斯细胞肿瘤的病理、临床及治疗方面进行简要概述。