Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan.
Department of Surgical Pathology, Aichi Medical University Hospital, Aichi, Japan.
Pathol Int. 2021 Jan;71(1):24-32. doi: 10.1111/pin.13044. Epub 2020 Nov 25.
Histiocytic and dendritic cell (H/DC) neoplasms are heterogeneous, originating from myeloid- or stromal-derived cells. Multiple reports describe the cross-lineage transdifferentiation of neoplastic B cells into H/DC neoplasms. Most such cases are from Western countries, and rarely from Japan or East Asia. Here we report 17 cases of H/DC neoplasms in Japanese patients, with analysis of t(14;18) by fluorescence in situ hybridization, and of neoplastic programmed death-ligand 1 (PD-L1) expression by immunostaining (clones SP142, E1J2J, and 28-8). These 17 cases were diagnosed according to the 2017 World Health Organization (WHO) classification, and included two histiocytic sarcomas (HS), two interdigitating cell (IDC) sarcomas, one Langerhans cell sarcoma, two dendritic cell sarcomas, and 10 follicular dendritic cell (FDC) sarcomas. No case had any past history of follicular lymphoma (FL). Two cases of HS and one IDC sarcoma, all of which were myeloid-driven, were found to exhibit t(14;18). In the latter case, at 30 months after IDC sarcoma diagnosis, FL development was detected. Three (30%) FDC sarcoma cases exhibited neoplastic PD-L1 expression with all the three PD-L1 antibody clones. This is the first report of t(14;18) and neoplastic PD-L1 expression on H/DC neoplasms among Japanese patients, each of which appeared to be associated with HS and FDC sarcoma, respectively.
组织细胞和树突状细胞（H/DC）肿瘤具有异质性，起源于髓系或基质衍生细胞。多项报道描述了肿瘤性 B 细胞向 H/DC 肿瘤的跨谱系转分化。大多数此类病例来自西方国家，很少来自日本或东亚。在这里，我们报告了 17 例日本患者的 H/DC 肿瘤病例，通过荧光原位杂交分析 t(14;18)，并用免疫染色（克隆 SP142、E1J2J 和 28-8）分析肿瘤程序性死亡配体 1（PD-L1）表达。这 17 例病例根据 2017 年世界卫生组织（WHO）分类诊断，包括 2 例组织细胞肉瘤（HS）、2 例滤泡树突状细胞肉瘤（FDC）肉瘤、1 例朗格汉斯细胞肉瘤、2 例交界性细胞肉瘤。没有病例有滤泡性淋巴瘤（FL）的既往病史。2 例 HS 和 1 例 IDC 肉瘤均为髓系驱动，发现存在 t(14;18)。在后一种情况下，在 IDC 肉瘤诊断后 30 个月，发现了 FL 的发展。3 例（30%）FDC 肉瘤病例用所有三种 PD-L1 抗体克隆均显示出肿瘤 PD-L1 表达。这是日本患者中 H/DC 肿瘤中 t(14;18)和肿瘤 PD-L1 表达的首次报道，分别与 HS 和 FDC 肉瘤相关。
