Park Joonseok, Jung Eun-Ha, Kim Changok, Choi Young Hee
Department of Clinical Pathology, EONE Reference Laboratory, Seoul, Korea.
Diagn Cytopathol. 2007 Aug;35(8):488-92. doi: 10.1002/dc.20665.
The objective of the study was to assess the clinical utility of a liquid-based cytology system on cervicovaginal screening in a clinical commercial laboratory. Twenty-six thousand, one hundred and seventy eight cervicovaginal specimens were prepared by the Liqui-PREP (LGM International Inc., Ft. Lauderdale, FL) with a direct-to-vial comparison to 218,548 cases of the conventional direct smear from August 2005 through December 2005. Biopsy data was obtained to confirm the sensitivity for each method. Liqui-PREP showed a marked increase in HSIL+ detection compared to the conventional smear ( P = 0.001). The rate of LSIL and AGC detection was higher with Liqui-PREP ( P equals; 0.001 for both). The percentage of ASCUS specimens was higher than with conventional smear due to cleaner slides and easier detection of suspicious cells. The WNL rate was lower for Liqui- PREP ( P = 0.001) consistent with increased HSIL+ and ASCUS. The unsatisfactory rate was lower for Liqui-PREP ( P = 0.017). The histological predictive value of Liqui-PREP was slightly higher than the conventional smear (94.1% versus 89.9%). The Liqui-PREP system similar to other reported LBC technologies shows an increased detection of squamous intraepithelial lesions, and gives higher-quality slides for interpretation than the conventional smear. Histological results confirm that this increase in cytological findings are clinically significant. LGM's new LBC technology is a more sensitive screening tool when compared with the conventional smear.
本研究的目的是评估一种液基细胞学系统在临床商业实验室用于宫颈阴道筛查的临床效用。2005年8月至2005年12月期间，使用Liqui-PREP（LGM国际公司，佛罗里达州劳德代尔堡）制备了26178份宫颈阴道标本，并与218548例传统直接涂片进行直接样本瓶对比。获取活检数据以确认每种方法的敏感性。与传统涂片相比，Liqui-PREP在高级别鳞状上皮内病变（HSIL+）检测方面有显著增加（P = 0.001）。Liqui-PREP的低级别鳞状上皮内病变（LSIL）和非典型腺细胞（AGC）检测率更高（两者P均等于0.001）。由于玻片更清洁且更容易检测，非典型鳞状细胞不能明确意义（ASCUS）标本的百分比高于传统涂片。Liqui-PREP的正常范围（WNL）率更低（P = 0.001），这与HSIL+和ASCUS增加一致。Liqui-PREP的不满意率更低（P = 0.017）。Liqui-PREP的组织学预测价值略高于传统涂片（94.1%对89.9%）。与其他报道的液基细胞学（LBC）技术类似，Liqui-PREP系统显示鳞状上皮内病变的检测增加，并且提供比传统涂片质量更高的玻片用于解读。组织学结果证实，细胞学发现的这种增加具有临床意义。与传统涂片相比，LGM的新型LBC技术是一种更敏感的筛查工具。
