Jahn P, Preuss M, Kernig A, Seifert-Hühmer A, Langer G
German Center for Evidence-based Nursing, Institute of Health and Nursing Sciences, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse 27, Halle/ Saale, Germany, 06097.
Cochrane Database Syst Rev. 2007 Jul 18(3):CD004997. doi: 10.1002/14651858.CD004997.pub2.
Prolonged urinary catheterisation is common amongst people in long-term care settings and this carries a high risk of developing a catheter-related urinary tract infection and associated complications. A variety of different kinds of urethral catheters are available. Some have been developed specifically to lower the risk of catheter-associated infection, for example antiseptic or antibiotic impregnated catheters. Ease of use, comfort and handling for the caregivers and patients, and cost-effectiveness are also important factors influencing choice.
The primary objective was to determine which type of in-dwelling urinary catheter is best to use for long-term bladder drainage in adults.
We searched the Cochrane Incontinence Group Specialised Trials Register (searched 15 December 2004), MEDLINE (January 1950 to February 2005) and CINAHL (January 1982 to February 2005). We also handsearched 28 relevant journals and conference proceedings. We examined the bibliographies of relevant articles and contacted catheter manufacturers, scientific societies and experts for trials.
All randomised trials comparing types of indwelling urinary catheters for long-term catheterisation in adults. Long-term catheterisation was defined as more than 30 days.
Data extraction has been undertaken by two review authors independently and simultaneously. Any disagreement has been resolved by a third review author. The included trial data were handled according to the description of the Cochrane Collaboration Reviewers' Handbook.
Three trials were included involving 102 adults in various settings. Two trials had a parallel group design and one was a randomised cross-over trial. Only two of the six targeted comparisons were assessed by these trials: antiseptic impregnated catheters versus standard catheters (one trial) and one type of standard catheter versus another standard catheter (two trials). The single small cross-over trial was inadequate to assess the value of silver alloy (antiseptic) impregnated catheters. In the two trials comparing different types of standard catheters, estimates of differences were all imprecise because the trials also had small sample sizes: confidence intervals were too wide to rule out clinically important differences. One trial did suggest, however, that the use of a hydrogel coated latex catheter rather than a silicone catheter may be better tolerated (RR for need for early removal 0.41, 95% CI 0.22 to 0.77).
AUTHORS' CONCLUSIONS: Very few trials have compared types of catheter for long-term bladder drainage. All were small and showed methodically weaknesses. Therefore, the evidence was not sufficient as a reliable basis for practical conclusions. Further, better quality trials are needed to address the current lack of evidence in this clinically important area.
长期护理机构中的人群长期留置导尿管的情况很常见,这会带来发生导尿管相关尿路感染及相关并发症的高风险。有多种不同类型的尿道导尿管可供使用。有些导尿管是专门为降低导尿管相关感染风险而研发的,例如抗菌或抗生素浸渍导尿管。导尿管的易用性、护理人员和患者的舒适度及操作便利性以及成本效益也是影响选择的重要因素。
主要目的是确定哪种类型的留置导尿管最适合用于成人长期膀胱引流。
我们检索了Cochrane尿失禁组专业试验注册库(检索时间为2004年12月15日)、MEDLINE(1950年1月至2005年2月)和CINAHL(1982年1月至2005年2月)。我们还手工检索了28种相关期刊和会议论文集。我们查阅了相关文章的参考文献,并联系了导尿管制造商、科学协会和专家以获取试验信息。
所有比较成人长期导尿用留置导尿管类型的随机试验。长期导尿定义为超过30天。
由两位综述作者独立且同时进行数据提取。如有分歧,由第三位综述作者解决。纳入试验的数据按照Cochrane协作网综述手册的描述进行处理。
纳入了三项试验,涉及102名处于不同环境的成人。两项试验采用平行组设计,一项是随机交叉试验。这些试验仅评估了六项目标比较中的两项:抗菌浸渍导尿管与标准导尿管(一项试验)以及一种标准导尿管与另一种标准导尿管(两项试验)。单一的小型交叉试验不足以评估银合金(抗菌)浸渍导尿管的价值。在两项比较不同类型标准导尿管的试验中,差异估计均不精确,因为试验样本量也较小:置信区间过宽,无法排除具有临床重要意义的差异。然而,一项试验确实表明,使用水凝胶涂层乳胶导尿管而非硅胶导尿管可能耐受性更好(早期拔除需求的相对风险为0.41,95%置信区间为0.22至0.77)。
很少有试验比较用于长期膀胱引流的导尿管类型。所有试验规模都较小且存在方法学上的弱点。因此,证据不足以作为得出实际结论的可靠依据。此外,需要开展质量更高的试验来解决这一临床重要领域目前证据不足的问题。