钙信号传导：丙酮酸与钙释放激活钙通道蛋白在十字路口相遇。

Calcium signaling: pyruvate and CRAC meet at the crossroads.

作者信息

Muallem Shmuel

机构信息

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Curr Biol. 2007 Jul 17;17(14):R549-51. doi: 10.1016/j.cub.2007.05.037.

DOI:10.1016/j.cub.2007.05.037

PMID:17637355

Abstract

Receptor-evoked Ca(2+) influx is mediated by store-operated Ca(2+) channels, such as the CRAC channel, which mediates the I(crac) current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates I(crac) to prolong Ca(2+) influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca(2+) influx by the CRAC channel.

摘要

受体诱发的Ca(2+)内流由储存操纵性Ca(2+)通道介导，如介导I(crac)电流的CRAC通道。最近的研究表明，三羧酸循环的前体底物丙酮酸可调节I(crac)，以延长Ca(2+)流入细胞，从而将葡萄糖氧化及其在线粒体中的自身代谢与CRAC通道介导的Ca(2+)内流相偶联。