Kano Yoko, Mitsuyama Yoko, Hirahara Kazuhisa, Shiohara Tetsuo
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
J Am Acad Dermatol. 2007 Aug;57(2 Suppl):S33-5. doi: 10.1016/j.jaad.2005.08.027.
Mycoplasma pneumoniae infection is one of the most common etiologic agents of respiratory tract diseases. Although the respiratory symptoms of this infection commonly are mild, it often is accompanied by various extrapulmonary complications including arthritis and cutaneous manifestations. We report 3 patients with M pneumoniae infection in a single family who revealed erythema nodosum, anaphylactoid purpura, and acute urticaria, respectively. We discuss the similarity between these cutaneous manifestations caused by this infection and those caused by viral infections, and the responsible factors for producing different cutaneous lesions by a single infectious agent in people with common genetic background. Age-related variations in cutaneous manifestations of M pneumoniae infections can be attributed to the immaturity of the adaptive immunity of a host, as has been suggested in viral infections.
肺炎支原体感染是呼吸道疾病最常见的病因之一。虽然这种感染的呼吸道症状通常较轻，但常伴有各种肺外并发症，包括关节炎和皮肤表现。我们报告了一个家庭中3例肺炎支原体感染患者，分别出现了结节性红斑、过敏性紫癜和急性荨麻疹。我们讨论了这种感染引起的皮肤表现与病毒感染引起的皮肤表现之间的相似性，以及在具有共同遗传背景的人群中，单一感染因子产生不同皮肤病变的相关因素。正如在病毒感染中所提示的那样，肺炎支原体感染皮肤表现的年龄相关差异可归因于宿主适应性免疫的不成熟。
