Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Dermatology, Bilecik State Hospital, Bilecik, Turkey.
J Immunol Res. 2017;2017:8139591. doi: 10.1155/2017/8139591. Epub 2017 May 28.
Even though infections are the most common cause of erythema nodosum (EN), only certain microorganisms take the great interest such as streptococci in knowledge. Our aim was to examine the frequency and type of infections in EN, to determine the characteristics of patients with an infectious etiology, and to discuss the role of these microbes in EN pathology in the context of their interactions with humans. Charts of 81 patients with EN who were seen between 2003 and 2017 were retrospectively reviewed. Identified etiological factors were classified into three groups: infectious, noninfectious, and idiopathic. While there were no significant demographic and clinical differences between the infectious and idiopathic groups, systemic symptoms ( = 0.034) and the number of EN lesions ( = 0.016) were significantly lower; the mean erythrocyte sedimentation rate was significantly higher ( = 0.049), but the mean aspartate aminotransferase value was significantly lower in the infectious group compared to the noninfectious group ( = 0.019). Besides streptococci, many other microbes, including the ones living on and inside us, were identified in the etiology of EN. There is a need for large-scale prospective studies involving control groups for a better understanding of the microbial immunopathology of EN.
尽管感染是结节性红斑（EN）最常见的原因，但只有某些微生物对链球菌等知识感兴趣。我们的目的是检查 EN 中感染的频率和类型，确定具有感染病因的患者的特征，并讨论这些微生物在 EN 病理学中的作用，以及它们与人类相互作用的关系。回顾性分析了 2003 年至 2017 年间就诊的 81 例 EN 患者的图表。确定的病因因素分为三组：感染性、非感染性和特发性。虽然感染组和特发性组在人口统计学和临床特征方面没有显著差异，但感染组的全身症状（=0.034）和 EN 病变数量（=0.016）明显较低；感染组的红细胞沉降率明显较高（=0.049），而丙氨酸氨基转移酶值明显较低（=0.019）。除链球菌外，在 EN 的病因中还发现了许多其他微生物，包括生活在我们体内和体内的微生物。需要进行大规模的前瞻性研究，包括对照组，以更好地了解 EN 的微生物免疫病理学。
