一种作为化疗和放疗模型的小鼠肾母细胞瘤。

A murine Wilms' tumor as a model for chemotherapy and radiotherapy.

作者信息

Tomashefsky P, Homsy Y L, Lattimer J K, Tannenbaum M

出版信息

J Natl Cancer Inst. 1976 Jan;56(1):137-42. doi: 10.1093/jnci/56.1.137.

DOI:10.1093/jnci/56.1.137

Abstract

We studied the effect on tumor volumes and host survival of twenty-four chemotherapeutic and radiotherapeutic regimens in rats bearing the Furth/Columbia murine Wilms' tumor. After 5 years and some 100 transfers, this tumor retained its sensitivity to suitable combinations of actinomycin D, vincristine, and X-ray, regimens in current use in the treatment of human Wilms' tumor. Cytoxan alone was highly inhibitory; adriamycin was modestly inhibitory; and lethal doses of methotrexate followed by leucovorin "rescue" were slightly inhibitory to the growth of the rat tumor. No other chemotherapeutic agent tested was effective by our criteria. Cytoxan, with or without adriamycin, and X-irradiation, were the most useful combinations studied. The chemotherapeutic agents given 3 days before irradiation were significantly more carcinostatic than they were when given after radiotherapy.

摘要

我们研究了24种化疗和放疗方案对携带Furth/哥伦比亚小鼠肾母细胞瘤的大鼠肿瘤体积和宿主存活的影响。经过5年和约100次传代后，该肿瘤对放线菌素D、长春新碱和X射线的合适组合仍保持敏感性，这些方案目前用于治疗人类肾母细胞瘤。单独使用环磷酰胺具有高度抑制作用；阿霉素具有中等抑制作用；致死剂量的甲氨蝶呤随后用亚叶酸“解救”对大鼠肿瘤生长有轻微抑制作用。根据我们的标准，所测试的其他化疗药物均无效。环磷酰胺（无论是否联合阿霉素）和X射线照射是所研究的最有效的组合。放疗前3天给予化疗药物的抑癌效果明显优于放疗后给予的效果。