Yerushalmi A
Br J Cancer. 1978 May;37(5):827-32. doi: 10.1038/bjc.1978.121.
(BALB/c X C57BL/6)F1 mice bearing an SV-40 fibrosarcoma in the limb were injected with 0.045, 0.09 and 0.18 microgram/g body wt actinomycin D into the tumour. Similar animals were also treated with local hyperthermia (39.7 degrees, 42.3 degrees and 43.6 degrees C intratumour temperature for 30 min). The marked increase in median survival time following the combination of drug and local hyperthermia indicates that the combined treatment has a synergistic effect in the control of solid tumours. The median survival time of animals receiving the two treatments in immediate succession was higher than in animals with 30 min between treatments. This has important implications for the therapy of human cancer.
将携带肢体SV - 40纤维肉瘤的（BALB/c×C57BL/6）F1小鼠，以每克体重0.045、0.09和0.18微克的放线菌素D注射到肿瘤内。对相似的动物也进行局部热疗（肿瘤内温度分别为39.7℃、42.3℃和43.6℃，持续30分钟）。药物与局部热疗联合后中位生存时间显著增加，表明联合治疗在实体瘤控制方面具有协同作用。两种治疗紧接着进行的动物的中位生存时间高于两次治疗间隔30分钟的动物。这对人类癌症治疗具有重要意义。
