Aylward E H, Schwartz J, Machlin S, Pearlson G
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
AJNR Am J Neuroradiol. 1991 Nov-Dec;12(6):1217-22.
Many studies have used ratios based on intercaudate distance as a measure of caudate atrophy and ratios based on bifrontal distance as a measure of ventricular enlargement independent of caudate atrophy. The purpose of the current study was to determine to what extent these ratios correlate with caudate area and volume and frontal horn area in various groups of patients. The three linear ratio measures, obtained from MR scans, were bicaudate ratio, bifrontal ratio, and bifrontal distance divided by bicaudate distance. Area and volume measures were corrected for brain size. Subjects included patients with autism, obsessive-compulsive disorder, and Huntington disease, as well as normal controls. As expected, the patients with Huntington disease had the largest bicaudate ratio, bifrontal ratio, and frontal horn area. Both bicaudate ratio and bifrontal ratio were fairly good measures of frontal horn size for most groups. Consistent with theoretical expectations, the bifrontal ratio was not highly correlated with caudate area or volume ratios. Bicaudate ratio and bifrontal distance/bicaudate distance were correlated with caudate volume for the patients with Huntington disease, but not for any of the other groups. Bifrontal distance/bicaudate distance was the best single predictor of caudate volume for all groups combined. It is concluded that bicaudate ratio and bifrontal distance/bicaudate distance are fairly good measures of caudate atrophy, but are poor measures of caudate size when no atrophy is present.
许多研究使用基于尾状核间距离的比率作为尾状核萎缩的度量指标，以及基于双额叶距离的比率作为与尾状核萎缩无关的脑室扩大的度量指标。本研究的目的是确定这些比率在不同患者组中与尾状核面积和体积以及额角面积的相关程度。从磁共振扫描中获得的三个线性比率测量指标分别是双侧尾状核比率、双额叶比率以及双额叶距离除以双侧尾状核距离。面积和体积测量指标已根据脑大小进行了校正。研究对象包括自闭症患者、强迫症患者、亨廷顿病患者以及正常对照组。正如预期的那样，亨廷顿病患者的双侧尾状核比率、双额叶比率和额角面积最大。对于大多数组而言，双侧尾状核比率和双额叶比率都是额角大小的相当不错的度量指标。与理论预期一致，双额叶比率与尾状核面积或体积比率的相关性并不高。双侧尾状核比率以及双额叶距离/双侧尾状核距离与亨廷顿病患者的尾状核体积相关，但与其他任何组均不相关。双额叶距离/双侧尾状核距离是所有组综合起来尾状核体积的最佳单一预测指标。研究得出结论，双侧尾状核比率和双额叶距离/双侧尾状核距离是尾状核萎缩的相当不错的度量指标，但在不存在萎缩时，它们是尾状核大小的较差度量指标。
