Milovanović Nebojša, Damjanović Aleksandar, Puškaš Laslo, Milovanović Srđan, Barišić Jasmina, Mališ Miloš, Stanković Gordana, Ranković Anka, Latas Milan, Filipović Branka F, Filipović Branislav R
Clinics for Psychiatry "Laza Lazarević", Belgrade, Serbia.
Psychiatr Danub. 2018 Jun;30(2):150-156. doi: 10.24869/psyd.2018.150.
In schizophrenia patients the lateral ventricle enlargement has mostly been reported in relationship with smaller cortical and/or subcortical brain volumes; and it has been observed that ventricular system growth may be a consequence of the smaller caudate nucleus volume. Bicaudate parameters have been used in the Alzheimer dementia and Huntington's chorea diagnosing in order to evaluate brain changes and the enlargement of the lateral ventricles.
This study has been carried out on 140 patients out of which 70 patients (30 men and 40 women) who met the ICD 10 criteria for schizophrenia and 70 healthy controls (30 men and 40 women) matched on sex and age with the studied group. All of them underwent direct caudatometry and volume computation based on MRI scans.
Except for the bicorporal line, for all the parameters were obtained the statistically highly significant differences between the examined and control groups. Significant correlation was established for the majority of bicaudate parameters and volumes of the caudate nuclei and lateral ventricles.
Enlargement of the lateral ventricles is one of the most frequent MRI finding in schizophrenia patients. Ventricles are enlarging gradually and frontal horns are more affected than other parts. The increased volumes of the caudate nuclei signalized that ventricular enlargement is not the consequence of the caudate atrophy.
Bicaudate parameters are reliable parameters for the quick orientation in order to assess the enlarged ventricles in schizophrenia patients.
在精神分裂症患者中，大多报告侧脑室扩大与较小的皮质和/或皮质下脑容量有关；并且观察到脑室系统增大可能是尾状核体积较小的结果。双侧尾状核参数已用于阿尔茨海默病性痴呆和亨廷顿舞蹈病的诊断，以评估脑部变化和侧脑室扩大情况。
本研究对140名患者进行，其中70名患者（30名男性和40名女性）符合国际疾病分类第10版精神分裂症标准，70名健康对照者（30名男性和40名女性）在性别和年龄上与研究组匹配。他们均接受了基于MRI扫描的直接尾状核测量和体积计算。
除双体线外，所有参数在被检查组和对照组之间均获得了具有统计学高度显著性的差异。大多数双侧尾状核参数与尾状核及侧脑室体积之间建立了显著相关性。
侧脑室扩大是精神分裂症患者最常见的MRI表现之一。脑室逐渐扩大，额角比其他部位受影响更大。尾状核体积增加表明脑室扩大不是尾状核萎缩的结果。
双侧尾状核参数是用于快速判断精神分裂症患者脑室扩大情况的可靠参数。
