Silver P A, Way J C
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Clin Pharmacol Ther. 2007 Nov;82(5):586-90. doi: 10.1038/sj.clpt.6100293. Epub 2007 Jul 18.
Molecular systems biology seeks to explain the behavior of complex cellular systems through a multicomponent analysis. We illustrate this approach and its relevance to drug development by reviewing two examples of the interplay between cellular processes and drugs: the internalization and recycling of oncogenic receptors, their ligands and therapeutic antibodies; and strategies for discovering drugs that affect intracellular protein kinase pathways.
