Mason Ivor
MRC Centre for Developmental Neurobiology, King's College London, Fourth floor New Hunt's House, Guy's Hospital Campus, London, SE1 1UL, UK.
Nat Rev Neurosci. 2007 Aug;8(8):583-96. doi: 10.1038/nrn2189.
From a wealth of experimental findings, derived from both in vitro and in vivo experiments, it is becoming clear that fibroblast growth factors regulate processes that are central to all aspects of nervous system development. Some of these functions are well known, whereas others, such as the roles of these proteins in axon guidance and synaptogenesis, have been established only recently. The emergent picture is one of remarkable economy, in which this family of ligands is deployed and redeployed at successive developmental stages to sculpt the nervous system.
从大量体外和体内实验得出的实验结果来看，成纤维细胞生长因子对神经系统发育各个方面的核心过程起到调控作用这一点正变得越来越清晰。其中一些功能广为人知，而其他功能，比如这些蛋白质在轴突导向和突触形成中的作用，则是直到最近才得以明确。呈现出的整体情况是一种显著的经济性，即在连续的发育阶段中，这一配体家族被反复利用来塑造神经系统。
