成纤维细胞生长因子在脊椎动物发育中的功能。

Functions of fibroblast growth factors in vertebrate development.

作者信息

Goldfarb M

机构信息

Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

Cytokine Growth Factor Rev. 1996 Dec;7(4):311-25. doi: 10.1016/s1359-6101(96)00039-1.

DOI:10.1016/s1359-6101(96)00039-1

PMID:9023055

Abstract

Fibroblast growth factors (FGFs) are a class of secreted polypeptide ligands which mediate diverse cellular responses during embryonic, fetal, and postnatal vertebrate development. The purposes of this review are to provide a condensed overview of FGFs and their receptors, to catalog and categorize the functions of FGFs in vertebrate development, to present recent discoveries relating to the interplay of FGFs with other secreted ligands in the control of tissue growth and patterning, and to discuss several potential directions for future research in the field.

摘要

成纤维细胞生长因子（FGFs）是一类分泌型多肽配体，在脊椎动物胚胎期、胎儿期及出生后的发育过程中介导多种细胞反应。本综述的目的是对FGFs及其受体进行简要概述，梳理并分类FGFs在脊椎动物发育中的功能，介绍FGFs与其他分泌型配体在组织生长和模式控制方面相互作用的最新发现，并探讨该领域未来研究的几个潜在方向。