诺氟沙星治疗志贺氏菌病的随机临床试验。
Randomized clinical trial of norfloxacin for shigellosis.
作者信息
Bhattacharya S K, Bhattacharya M K, Dutta P, Sen D, Rasaily R, Moitra A, Pal S C
机构信息
National Institute of Cholera and Enteric Diseases, Calcutta, India.
出版信息
Am J Trop Med Hyg. 1991 Dec;45(6):683-7. doi: 10.4269/ajtmh.1991.45.683.
In a randomized clinical trial, norfloxacin was compared with nalidixic acid in the treatment of acute invasive diarrhea, with particular reference to shigellosis in adults. Of 104 patients studied, 40 were positive for Shigella in stool cultures, of which 22 received norfloxacin and 18 received nalidixic acid. The patients in these two groups were comparable on admission. In the treatment of culture-positive shigellosis cases, the responses to therapy with both drugs were similar, except that the duration of fever, anorexia, and abdominal pain were less in those who received norfloxacin. Norfloxacin appeared to be superior to nalidixic acid in the treatment of shigellosis cases caused by Shigella strains resistant to nalidixic acid.
在一项随机临床试验中，对诺氟沙星和萘啶酸治疗急性侵袭性腹泻（特别是成人志贺氏菌病）进行了比较。在研究的104例患者中，40例粪便培养志贺氏菌呈阳性，其中22例接受诺氟沙星治疗，18例接受萘啶酸治疗。这两组患者入院时情况相当。在治疗培养阳性的志贺氏菌病病例时，两种药物的治疗反应相似，但接受诺氟沙星治疗的患者发热、厌食和腹痛的持续时间较短。在治疗对萘啶酸耐药的志贺氏菌菌株引起的志贺氏菌病病例时，诺氟沙星似乎优于萘啶酸。
Zotero 插件