诺氟沙星与萘啶酸治疗成人志贺氏痢疾杆菌1型所致痢疾的比较。
Comparison of norfloxacin and nalidixic acid for treatment of dysentery caused by Shigella dysenteriae type 1 in adults.
作者信息
Rogerie F, Ott D, Vandepitte J, Verbist L, Lemmens P, Habiyaremye I
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):883-6. doi: 10.1128/AAC.29.5.883.
Abstract
A severe epidemic of dysentery began late in 1979 in northeast Zaire and spread to Rwanda, Burundi, and Tanzania. The epidemic strain is a multiply resistant Shigella dysenteriae type 1, which acquired resistance against trimethoprim and more recently against nalidixic acid in the course of the epidemic. A comparative open trial in Rwandan adults with Shiga dysentery involved 18 patients treated with norfloxacin at 400 mg twice daily and 12 patients treated with nalidixic acid at 1 g three times daily for 5 days. All isolates showed in vitro susceptibility to both drugs. Though norfloxacin eliminated Shigella organisms from stools more rapidly than nalidixic acid, its clinical superiority did not reach the level of significance. Norfloxacin is a promising drug and is more effective than nalidixic acid in the treatment of multiresistant shigellosis.
摘要
1979年末，扎伊尔东北部暴发了严重的痢疾疫情，并蔓延至卢旺达、布隆迪和坦桑尼亚。流行菌株为多重耐药的1型志贺氏痢疾杆菌，在疫情期间获得了对甲氧苄啶的耐药性，最近又对萘啶酸产生了耐药性。在卢旺达成年人中进行的一项关于志贺氏痢疾的比较开放性试验，18名患者每日两次服用400毫克诺氟沙星，12名患者每日三次服用1克萘啶酸，疗程均为5天。所有分离株在体外对两种药物均敏感。虽然诺氟沙星比萘啶酸更快地从粪便中清除志贺氏菌，但它的临床优势未达到显著水平。诺氟沙星是一种有前景的药物，在治疗多重耐药性志贺氏菌病方面比萘啶酸更有效。
相似文献
1
Comparison of norfloxacin and nalidixic acid for treatment of dysentery caused by Shigella dysenteriae type 1 in adults.诺氟沙星与萘啶酸治疗成人志贺氏痢疾杆菌1型所致痢疾的比较。
Antimicrob Agents Chemother. 1986 May;29(5):883-6. doi: 10.1128/AAC.29.5.883.
2
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial.
J Diarrhoeal Dis Res. 1992 Sep;10(3):146-50.
3
Randomized clinical trial of norfloxacin for shigellosis.诺氟沙星治疗志贺氏菌病的随机临床试验。
Am J Trop Med Hyg. 1991 Dec;45(6):683-7. doi: 10.4269/ajtmh.1991.45.683.
4
Treatment of bacillary dysentery: a comparison between enoxacin and nalidixic acid.
J Antimicrob Chemother. 1987 May;19(5):695-8. doi: 10.1093/jac/19.5.695.
5
Outbreak of dysentery due to nalidixic acid resistant S. dysenteriae 1 at Agartala, Tripura: a hospital based study.印度特里普拉邦阿加尔塔拉市由耐萘啶酸痢疾志贺菌1型引起的痢疾暴发：一项基于医院的研究
Indian J Public Health. 1990 Jan-Mar;34(1):11-4.
6
Epidemic Shiga bacillus dysentery in Central Africa.中非的志贺氏菌流行性痢疾
Am J Trop Med Hyg. 1984 Nov;33(6):1192-7. doi: 10.4269/ajtmh.1984.33.1192.
7
Epidemic dysentery caused by Shigella dysenteriae type 1: a sentinel site surveillance of antimicrobial resistance patterns in Burundi.由1型痢疾志贺菌引起的流行性痢疾：布隆迪抗菌药物耐药模式的哨点监测
Bull World Health Organ. 1995;73(6):787-91.
8
Antimicrobial resistance and serotypes of Shigella isolates in Kigali, Rwanda (1983 to 1993): increasing frequency of multiple resistance.卢旺达基加利志贺氏菌分离株的抗微生物耐药性及血清型（1983年至1993年）：多重耐药频率增加
Diagn Microbiol Infect Dis. 1997 Aug;28(4):165-71. doi: 10.1016/s0732-8893(97)00072-2.
9
Plasmid characterization of drug-resistant Shigella dysenteriae 1 from an epidemic in Central Africa.来自中非一次疫情的耐药性痢疾志贺氏菌1型的质粒特征分析
J Hyg (Lond). 1985 Apr;94(2):163-72. doi: 10.1017/s0022172400061362.
10
[An outbreak of Shigella dysenteriae type 1 dysentery in a refugee camp in Rwanda].[卢旺达难民营中1型志贺氏痢疾杆菌痢疾的爆发]
Sante. 1995 May-Jun;5(3):181-4.
引用本文的文献
1
Transferable Mechanisms of Quinolone Resistance from 1998 Onward.1998 年以来喹诺酮类耐药的可转移机制。
Clin Microbiol Rev. 2019 Aug 14;32(4). doi: 10.1128/CMR.00007-19. Print 2019 Sep 18.
2
Efficacy and potential of phage therapy against multidrug resistant spp.噬菌体疗法对多重耐药菌的疗效及潜力
PeerJ. 2019 Apr 5;7:e6225. doi: 10.7717/peerj.6225. eCollection 2019.
3
Antibiotic therapy for Shigella dysentery.志贺氏菌痢疾的抗生素治疗
Cochrane Database Syst Rev. 2010 Aug 4;2010(8):CD006784. doi: 10.1002/14651858.CD006784.pub4.
4
A look back at an ongoing problem: Shigella dysenteriae type 1 epidemics in refugee settings in Central Africa (1993-1995).回顾一个持续存在的问题：1993 - 1995年中非难民环境中的1型志贺氏痢疾杆菌疫情。
PLoS One. 2009;4(2):e4494. doi: 10.1371/journal.pone.0004494. Epub 2009 Feb 13.
5
Using European travellers as an early alert to detect emerging pathogens in countries with limited laboratory resources.利用欧洲旅行者作为早期预警，在实验室资源有限的国家检测新出现的病原体。
BMC Public Health. 2007 Jan 19;7:8. doi: 10.1186/1471-2458-7-8.
6
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.四个地理区域中引起旅行者腹泻的细菌性肠道病原体的体外抗菌药敏试验。
Antimicrob Agents Chemother. 2001 Jan;45(1):212-6. doi: 10.1128/AAC.45.1.212-216.2001.
7
The new quinolones in the treatment of diarrhoea and typhoid fever.新型喹诺酮类药物在腹泻和伤寒治疗中的应用
Drugs. 1995;49 Suppl 2:132-5. doi: 10.2165/00003495-199500492-00021.
8
Acute bacterial diarrhoea in the emergency room: therapeutic implications of stool culture results.急诊室中的急性细菌性腹泻：粪便培养结果的治疗意义
J Accid Emerg Med. 1994 Sep;11(3):168-71. doi: 10.1136/emj.11.3.168.
9
Quinolones in the treatment of acute bacterial diarrhoeal diseases.喹诺酮类药物在急性细菌性腹泻疾病治疗中的应用
Drugs. 1993;45 Suppl 3:114-8. doi: 10.2165/00003495-199300453-00019.
10
Problems in identification of Campylobacter jejuni associated with acquisition of resistance to nalidixic acid.空肠弯曲菌鉴定中与获得对萘啶酸耐药性相关的问题。
J Clin Microbiol. 1987 Sep;25(9):1807-8. doi: 10.1128/jcm.25.9.1807-1808.1987.
本文引用的文献
1
Controlled comparison of nalidixic acid or lactulose with placebo in shigellosis.萘啶酸或乳果糖与安慰剂治疗志贺菌病的对照比较。
Scand J Infect Dis. 1981;13(3):191-3. doi: 10.3109/inf.1981.13.issue-3.06.
2
Comparative in vitro activities of ten antimicrobial agents against bacterial enteropathogens.十种抗菌剂对细菌性肠道病原体的体外活性比较
Antimicrob Agents Chemother. 1983 Oct;24(4):509-13. doi: 10.1128/AAC.24.4.509.
3
A bacillary dysentery epidemic in Dar es Salaam, Tanzania.坦桑尼亚达累斯萨拉姆的一场细菌性痢疾疫情。
J Diarrhoeal Dis Res. 1984 Dec;2(4):217-22.
4
Drug resistance in Shigella dysenteriae, S flexneri and S boydii in England and Wales: increasing incidence of resistance to trimethoprim.英格兰和威尔士痢疾志贺菌、福氏志贺菌和鲍氏志贺菌的耐药性：对甲氧苄啶耐药率不断上升。
Br Med J (Clin Res Ed). 1984 Mar 10;288(6419):784-6. doi: 10.1136/bmj.288.6419.784.
5
Epidemic Shiga bacillus dysentery in Central Africa.中非的志贺氏菌流行性痢疾
Am J Trop Med Hyg. 1984 Nov;33(6):1192-7. doi: 10.4269/ajtmh.1984.33.1192.
6
Outbreak of Shigella dysentery in Eastern Zaire, 1980-1982.1980 - 1982年扎伊尔东部志贺氏菌痢疾暴发。
Ann Soc Belg Med Trop. 1983 Mar;63(1):59-67.
7
The comparative activity of norfloxacin with other antimicrobial agents against Gram-positive and Gram-negative bacteria.诺氟沙星与其他抗菌剂对革兰氏阳性菌和革兰氏阴性菌的比较活性。
J Antimicrob Chemother. 1983 Apr;11(4):369-76. doi: 10.1093/jac/11.4.369.
8
In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.诺氟沙星（MK - 0366，AM - 715）及其他药物对胃肠道病原体的体外抗菌活性。
Antimicrob Agents Chemother. 1983 Jan;23(1):86-90. doi: 10.1128/AAC.23.1.86.
9
Epidemic of dysentery in West Bengal: clinicians' enigma.西孟加拉邦的痢疾疫情：临床医生的谜题。
Lancet. 1984 Nov 17;2(8412):1160. doi: 10.1016/s0140-6736(84)91600-3.
10
Nalidixic acid analogues and Shigella.萘啶酸类似物与志贺氏菌
Lancet. 1984 Jul 21;2(8395):172-3. doi: 10.1016/s0140-6736(84)91094-8.
Zotero 插件