Besouw Martine T P, Levtchenko Elena N, Willemsen Michèl A A P, Noordam Kees
Department of Pediatric Nephrology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
Pediatr Nephrol. 2008 Feb;23(2):307-10. doi: 10.1007/s00467-007-0543-x. Epub 2007 Jul 19.
Juvenile cystinosis was diagnosed in a patient who presented with severe headache attacks and photophobia. Treatment with oral cysteamine and topical cysteamine eye drops was started. One-and-a-half years later, he developed unilateral gynecomastia and elevated prolactin and growth hormone levels. A pituitary macroprolactinoma was discovered and successfully treated with the dopamine agonist cabergoline. Increased serum growth hormone levels were attributed to enhanced growth hormone production by the prolactinoma and somatostatin inhibition by cysteamine. Although the occurrence of prolactinoma in this patient could be a simple coincidence, it might also be a rare yet unrecognised complication of cystinosis.
一名出现严重头痛发作和畏光症状的患者被诊断为青少年胱氨酸病。开始使用口服半胱胺和局部用半胱胺滴眼液进行治疗。一年半后，他出现单侧乳腺增生以及催乳素和生长激素水平升高。发现了垂体大催乳素瘤，并成功使用多巴胺激动剂卡麦角林进行了治疗。血清生长激素水平升高归因于催乳素瘤产生生长激素增加以及半胱胺对生长抑素的抑制作用。尽管该患者催乳素瘤的发生可能只是一个巧合，但也可能是胱氨酸病一种罕见但未被认识的并发症。
