垂体的发育与生理学

Pituitary development and physiology.

作者信息

Cheung Clement C, Lustig Robert H

机构信息

Department of Pediatrics, University of California, San Francisco, CA 94142, USA.

出版信息

Pituitary. 2007;10(4):335-50. doi: 10.1007/s11102-007-0051-9.

DOI:10.1007/s11102-007-0051-9

PMID:17638086

Abstract

The functions of the pituitary hormones have been relatively well studied; however, understanding the regulation of their synthesis and release have been an ongoing subject of intense research. This review provides an overview of the pituitary cell types and their hormone products. Current understanding of the expression and regulation of the pituitary hormone genes, control of the synthesis and release of the corresponding hormones, and developmental changes are reviewed. This review concludes with a discussion of several of these genes and the genetic disorders with which they are associated.

摘要

垂体激素的功能已得到较为充分的研究；然而，了解其合成和释放的调节一直是深入研究的一个持续课题。本综述概述了垂体细胞类型及其激素产物。文中回顾了目前对垂体激素基因的表达和调节、相应激素合成和释放的控制以及发育变化的理解。本综述最后讨论了其中的几个基因以及与之相关的遗传疾病。