激肽拮抗剂 Hoe 140 可减少角叉菜胶、缓激肽和高岭土引起的大鼠急性爪肿胀。

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin.

机构信息

Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.

出版信息

Inflammopharmacology. 1998;6(1):9-17. doi: 10.1007/s10787-998-0002-8.

DOI:10.1007/s10787-998-0002-8

PMID:17638123

Abstract

The present study aimed to evaluate the effect of Hoe 140, a BK receptor B(2) antagonist, on acute oedema induced by carrageenan, BK and kaolin in male Wistar Kyoto rats. Hoe 140 (0.2 mg/kg and 20 mg/kg) given ip caused significant (p<0.05 and p<0.01) inhibition of carrageenan and BK-induced paw oedema. This suggests that BK is the prime inflammatory mediator of carrageenan oedema, and that it is also a specific blocker of oedema caused by BK. Furthermore, Hoe 140 was found to be less effective in reducing kaolin-induced oedema in rats. This might reflect that BK is not a prime inflammatory mediator of kaolin-induced oedema. The possible significance of these findings is discussed.

摘要

本研究旨在评估 Hoe 140（一种 BK 受体 B(2)拮抗剂）对雄性 Wistar 京都大鼠角叉菜胶、BK 和高岭土诱导的急性水肿的影响。Hoe 140（0.2 mg/kg 和 20 mg/kg）腹腔给药可显著抑制（p<0.05 和 p<0.01）角叉菜胶和 BK 诱导的爪水肿。这表明 BK 是角叉菜胶水肿的主要炎症介质，并且它也是 BK 诱导的水肿的特异性阻滞剂。此外，发现 Hoe 140 对大鼠高岭土诱导的水肿的减轻作用较小。这可能反映 BK 不是高岭土诱导的水肿的主要炎症介质。讨论了这些发现的可能意义。