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在资源有限环境（乌干达）中，与核苷类似物逆转录酶抑制剂用于HIV感染患者相关的症状性高乳酸血症：24例报告

Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda).

作者信息

Songa Patricia Mwebaze, Castelnuovo Barbara, Mugasha Estella Birabwa, Ocama Ponsiano, Kambugu Andrew

机构信息

Infectious Diseases Institute, Makerere University, Kampala, Uganda.

出版信息

Clin Infect Dis. 2007 Aug 15;45(4):514-7. doi: 10.1086/520023. Epub 2007 Jul 5.

DOI:10.1086/520023
PMID:17638205
Abstract

We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that contained stavudine. The median serum lactate level was 6.6 mmol/L. All patients had their antiretroviral treatment regimen discontinued. Hospital admission was required for 5 patients. Five patients died.

摘要

我们描述了24例乌干达人类免疫缺陷病毒感染患者，他们在使用核苷类似物后出现了有症状的高乳酸血症。所有患者都在接受包含司他夫定的联合治疗。血清乳酸水平中位数为6.6毫摩尔/升。所有患者都停止了抗逆转录病毒治疗方案。5名患者需要住院治疗。5名患者死亡。

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