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Clin Infect Dis. 2007 Aug 15;45(4):514-7. doi: 10.1086/520023. Epub 2007 Jul 5.
2
A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa.在南非索韦托接受高效抗逆转录病毒治疗的女性中，乳酸酸中毒和症状性高乳酸血症的发生率很高。
Clin Infect Dis. 2007 Jul 15;45(2):254-60. doi: 10.1086/518976. Epub 2007 Jun 8.
3
Lack of recurrence of hyperlactatemia in HIV-infected patients switched from stavudine to abacavir or zidovudine.从司他夫定转换为阿巴卡韦或齐多夫定的HIV感染患者中高乳酸血症未复发。
J Acquir Immune Defic Syndr. 2004 Aug 1;36(4):935-42. doi: 10.1097/00126334-200408010-00007.
4
Safety and efficacy of switching to alternative nucleoside analogues following symptomatic hyperlactatemia and lactic acidosis.出现症状性高乳酸血症和乳酸性酸中毒后换用其他核苷类似物的安全性和有效性。
AIDS. 2003 Nov 21;17(17):2495-9. doi: 10.1097/00002030-200311210-00012.
5
Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors.抗逆转录病毒治疗期间的高乳酸血症和乳酸性酸中毒：相关性、可重复性及可能的危险因素。
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6
Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study.高乳酸血症与抗逆转录病毒疗法：瑞士HIV队列研究
Clin Infect Dis. 2001 Dec 1;33(11):1931-7. doi: 10.1086/324353. Epub 2001 Oct 23.
7
A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.一种与HIV核苷类似物治疗相关的脂肪萎缩、乳酸性酸中毒和肝功能障碍综合征：对蛋白酶抑制剂相关脂肪代谢障碍综合征的影响。
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8
Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature.
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出现症状性高乳酸血症后从司他夫定换用齐多夫定是否安全？

Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?

作者信息

Castelnuovo Barbara, Nanyonjo Agnes, Kamya Moses, Ocama Ponsiano

机构信息

Infectious Diseases Institute, Kampala, Uganda.

出版信息

Afr Health Sci. 2008 Jun;8(2):133-4.

PMID:19357764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2584324/
Abstract

INTRODUCTION

In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.

CASE REPORT

We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.

DISCUSSION

This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse. Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.

摘要

引言

在资源有限的环境中，接受抗逆转录病毒治疗且出现司他夫定诱导的高乳酸血症的患者，通常会根据已发表的研究结果转而使用齐多夫定，这些研究表明该药物可以作为一种安全的替代药物。

病例报告

我们在此描述一名60岁女性的病例，该患者在从司他夫定换用齐多夫定后出现有症状的高乳酸血症复发，以及该病例在乌干达坎帕拉传染病研究所的处理情况。

讨论

该病例表明，换用齐多夫定可能会导致高乳酸血症复发。因此，我们建议对从司他夫定换用齐多夫定的患者进行密切随访，并且在无法进行乳酸测量的情况下，免费项目应为出现高乳酸血症的患者提供更安全的药物，如阿巴卡韦和替诺福韦。