• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

家族性帕金森病中的线粒体细胞死亡控制

Mitochondrial cell death control in familial Parkinson disease.

作者信息

Kroemer Guido, Blomgren Klas

机构信息

INSERM, U848, Institut Gustave Roussy, Université de Paris-Sud, Paris 11, Villejuif, France.

出版信息

PLoS Biol. 2007 Jul;5(7):e206. doi: 10.1371/journal.pbio.0050206. Epub 2007 Jul 17.

DOI:10.1371/journal.pbio.0050206
PMID:17638420
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1914412/
Abstract

Many sporadic cases of Parkinsons disease have mutations in the PINK protein kinase, whose substrate is now revealed to be a protein that protects mitochondria from oxidative stress.

摘要

许多散发性帕金森病病例在PINK蛋白激酶中存在突变，其底物现已被揭示为一种保护线粒体免受氧化应激的蛋白质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a55/1914412/c40c8f163e0e/pbio.0050206.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a55/1914412/c40c8f163e0e/pbio.0050206.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a55/1914412/c40c8f163e0e/pbio.0050206.g001.jpg

相似文献

1
Mitochondrial cell death control in familial Parkinson disease.家族性帕金森病中的线粒体细胞死亡控制
PLoS Biol. 2007 Jul;5(7):e206. doi: 10.1371/journal.pbio.0050206. Epub 2007 Jul 17.
2
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.PINK1通过磷酸化线粒体伴侣蛋白TRAP1来抵御氧化应激。
PLoS Biol. 2007 Jul;5(7):e172. doi: 10.1371/journal.pbio.0050172. Epub 2007 Jun 19.
3
PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.与隐性帕金森病相关的PINK1突变体在抑制细胞色素c的线粒体释放方面存在缺陷。
Neurobiol Dis. 2007 Nov;28(2):216-26. doi: 10.1016/j.nbd.2007.07.010. Epub 2007 Jul 17.
4
Parkinson's disease: pro-survival effects of PINK1.帕金森病：PINK1的促生存作用
Nature. 2007 Aug 16;448(7155):759-60. doi: 10.1038/448759a.
5
Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway.一种新型16.2 kD热休克蛋白主要通过Hsp90介导的脂筏稳定和Akt激活途径抑制细胞死亡。
Apoptosis. 2007 Jan;12(1):97-112. doi: 10.1007/s10495-006-0486-x.
6
Mitochondria and dopamine: new insights into recessive parkinsonism.线粒体与多巴胺：对隐性帕金森病的新见解
Neuron. 2004 Aug 5;43(3):301-4. doi: 10.1016/j.neuron.2004.07.012.
7
RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells.RA410/Sly1抑制MPP+和6-羟基多巴胺诱导的SH-SY5Y细胞死亡。
Neurobiol Dis. 2005 Feb;18(1):143-51. doi: 10.1016/j.nbd.2004.09.008.
8
Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway.热应激通过抑制3-磷酸肌醇依赖性激酶1/Akt途径使间皮瘤细胞对肿瘤坏死因子相关凋亡诱导配体诱导的凋亡敏感。
Cancer Res. 2007 Mar 15;67(6):2865-71. doi: 10.1158/0008-5472.CAN-06-3871.
9
Dopaminergic neurons reduced to silence by oxidative stress: an early step in the death cascade in Parkinson's disease?多巴胺能神经元因氧化应激而沉默：帕金森病死亡级联反应的早期步骤？
Sci STKE. 2006 Apr 25;2006(332):pe19. doi: 10.1126/stke.3322006pe19.
10
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.α-突触核蛋白在MPTP损伤的非人灵长类动物黑质中的表达。
Neurobiol Dis. 2005 Dec;20(3):898-906. doi: 10.1016/j.nbd.2005.05.028. Epub 2005 Jul 11.

引用本文的文献

1
Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore.Caspase-3 切割的 tau 通过打开线粒体通透性转换孔来损害线粒体功能。
Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166898. doi: 10.1016/j.bbadis.2023.166898. Epub 2023 Sep 28.
2
Ameliorative effects and possible molecular mechanisms of action of fibrauretine from Pierre on d-galactose/AlCl-mediated Alzheimer's disease.粉防己碱对D-半乳糖/氯化铝介导的阿尔茨海默病的改善作用及可能的分子作用机制
RSC Adv. 2018 Sep 10;8(55):31646-31657. doi: 10.1039/c8ra05356a. eCollection 2018 Sep 5.
3

本文引用的文献

1
Mitochondrial membrane permeabilization in cell death.细胞死亡中的线粒体膜通透性改变
Physiol Rev. 2007 Jan;87(1):99-163. doi: 10.1152/physrev.00013.2006.
2
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties.热休克蛋白27和70：具有致瘤特性的抗凋亡蛋白。
Cell Cycle. 2006 Nov;5(22):2592-601. doi: 10.4161/cc.5.22.3448. Epub 2006 Nov 15.
3
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.
TRAP1 in Oxidative Stress and Neurodegeneration.
氧化应激与神经退行性变中的TRAP1
Antioxidants (Basel). 2021 Nov 19;10(11):1829. doi: 10.3390/antiox10111829.
4
Impact of Tau on Neurovascular Pathology in Alzheimer's Disease.Tau蛋白对阿尔茨海默病神经血管病理的影响
Front Neurol. 2021 Jan 7;11:573324. doi: 10.3389/fneur.2020.573324. eCollection 2020.
5
The bimodal mechanism of interaction between dopamine and mitochondria as reflected in Parkinson's disease and in schizophrenia.多巴胺与线粒体相互作用的双模态机制在帕金森病和精神分裂症中的反映。
J Neural Transm (Vienna). 2020 Feb;127(2):159-168. doi: 10.1007/s00702-019-02120-x. Epub 2019 Dec 17.
6
Protects d-Galactose/AlCl Mediated Alzheimer's Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus.通过在其海马体中的 PP2A/GSK-3β 信号通路保护 d-半乳糖/AlCl 介导的阿尔茨海默病样大鼠。
Int J Mol Sci. 2019 Apr 16;20(8):1871. doi: 10.3390/ijms20081871.
7
Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration.Tau病理在神经退行性变中线粒体损伤中的作用。
Front Neurosci. 2018 Jul 5;12:441. doi: 10.3389/fnins.2018.00441. eCollection 2018.
8
Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts.将帕金森病的风险因素整合到 2 个大型纵向队列中。
Neurology. 2018 May 8;90(19):e1646-e1653. doi: 10.1212/WNL.0000000000005473. Epub 2018 Apr 11.
9
Ginsenoside Rb1 inhibit apoptosis in rat model of Alzheimer's disease induced by Aβ.人参皂苷Rb1抑制由Aβ诱导的阿尔茨海默病大鼠模型中的细胞凋亡。
Am J Transl Res. 2018 Mar 15;10(3):796-805. eCollection 2018.
10
Let-7d microRNA Attenuates 6-OHDA-Induced Injury by Targeting Caspase-3 in MN9D Cells.Let-7d 微 RNA 通过靶向 MN9D 细胞中的 Caspase-3 来减轻 6-OHDA 诱导的损伤。
J Mol Neurosci. 2017 Dec;63(3-4):403-411. doi: 10.1007/s12031-017-0994-x. Epub 2017 Oct 29.
C 末端截短和帕金森病相关突变下调 PTEN 诱导激酶 1 的蛋白丝氨酸/苏氨酸激酶活性。
Hum Mol Genet. 2006 Nov 1;15(21):3251-62. doi: 10.1093/hmg/ddl398. Epub 2006 Sep 25.
4
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.抗氧化剂可保护果蝇中依赖PINK1的多巴胺能神经元。
Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13520-5. doi: 10.1073/pnas.0604661103. Epub 2006 Aug 24.
5
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.果蝇Pink1失活所导致的线粒体病理以及肌肉和多巴胺能神经元退化可被Parkin挽救。
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10793-8. doi: 10.1073/pnas.0602493103. Epub 2006 Jul 3.
6
Mitochondrial disease.线粒体疾病
Lancet. 2006 Jul 1;368(9529):70-82. doi: 10.1016/S0140-6736(06)68970-8.
7
PINK1 protein in normal human brain and Parkinson's disease.正常人类大脑和帕金森病中的PINK1蛋白
Brain. 2006 Jul;129(Pt 7):1720-31. doi: 10.1093/brain/awl114. Epub 2006 May 15.
8
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.果蝇粉色1基因是线粒体功能所必需的，并且在遗传学上与帕金蛋白相互作用。
Nature. 2006 Jun 29;441(7097):1162-6. doi: 10.1038/nature04779. Epub 2006 May 3.
9
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.果蝇PINK1突变体中的线粒体功能障碍可被帕金蛋白弥补。
Nature. 2006 Jun 29;441(7097):1157-61. doi: 10.1038/nature04788. Epub 2006 May 3.
10
Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients.纯合子和杂合子PINK1突变：帕金森病患者诊断与护理的考量因素
Mov Disord. 2006 Jun;21(6):875-9. doi: 10.1002/mds.20854.