耻垢分枝杆菌对一氧化氮抗菌活性的天然保护作用由巯基乙醇酸提供。
Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.
作者信息
Miller Christopher C, Rawat Mamta, Johnson Todd, Av-Gay Yossef
机构信息
Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St., Vancouver, BC, Canada V5Z 3J5.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3364-6. doi: 10.1128/AAC.00347-07. Epub 2007 Jul 16.
Abstract
Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.
摘要
一氧化氮（NO）是一种有效的抗菌剂。耻垢分枝杆菌突变体对NO敏感，这表明了巯基乙醇在保护分枝杆菌免受亚硝化损伤方面的作用。NO与巯基乙醇水平之间的直接相关性证实，巯基乙醇对于保护分枝杆菌免受NO攻击很重要。
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