Criscione Vincent D, Weinstock Martin A
Dermatoepidemiology Unit-111D, VA Medical Center, 830 Chalkstone Ave, Providence, RI 02908-4799, USA.
Arch Dermatol. 2007 Jul;143(7):854-9. doi: 10.1001/archderm.143.7.854.
To describe incidence trends for cutaneous T-cell lymphoma (CTCL) in the United States.
Population-based study.
Data were obtained from 13 population-based cancer registries of the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute from 1973 through 2002.
A total of 4783 cases of CTCL were identified for the period 1973 through 2002.
Diagnosis of CTCL.
The overall annual age-adjusted incidence of CTCL was 6.4 per million persons. Annual incidence increased by 2.9 x 10(-6) per decade over the study period. Incidence was higher among blacks (9.0 x 10(-6)) than among whites (6.1 x 10(-6)) and was higher among men (8.7 x 10(-6)) than among women (4.6 x 10(-6)). The racial differences in incidence decreased with age, while the sex differences increased with age and decreased over time. Substantial geographic variation in incidence was found. Incidence was correlated with high physician density, high family income, high percentage of population with a bachelor's degree or higher, and high home values. Changes in International Classification of Diseases for Oncology (ICD-O) morphologic definitions have resulted in the redistribution of the cases of CTCL among specific subclassifications.
The continued rise in incidence of CTCL is substantial, and the cause of this increase is unknown. The racial, ethnic, sex, and geographic differences in incidence may be of etiologic importance. Changes in ICD-O definitions have made it difficult to evaluate incidence trends for subclassifications of CTCL such as mycosis fungoides. In addition, these changes resulted in the creation of ambiguous histologic codes, which may have caused coding errors. These errors along with the lack of independent verification are limitations of our study. An epidemiological investigation using population-based data is important to better understand this disorder.
描述美国皮肤T细胞淋巴瘤（CTCL）的发病趋势。
基于人群的研究。
数据来自1973年至2002年美国国立癌症研究所监测、流行病学和最终结果（SEER）计划的13个基于人群的癌症登记处。
1973年至2002年期间共识别出4783例CTCL病例。
CTCL的诊断。
CTCL的总体年龄调整后年发病率为每百万人6.4例。在研究期间，年发病率每十年增加2.9×10⁻⁶。黑人（9.0×10⁻⁶）的发病率高于白人（6.1×10⁻⁶），男性（8.7×10⁻⁶）的发病率高于女性（4.6×10⁻⁶）。发病率的种族差异随年龄增长而减小，而性别差异随年龄增长而增大且随时间推移而减小。发现发病率存在显著的地理差异。发病率与高医生密度、高家庭收入、拥有学士学位或更高学历的人口高比例以及高房价相关。国际肿瘤疾病分类（ICD - O）形态学定义的变化导致CTCL病例在特定亚分类中的重新分布。
CTCL发病率持续显著上升，其增加原因不明。发病率的种族、民族、性别和地理差异可能具有病因学意义。ICD - O定义的变化使得难以评估CTCL亚分类（如蕈样肉芽肿）的发病趋势。此外，这些变化导致了模糊的组织学编码的产生，这可能导致编码错误。这些错误以及缺乏独立验证是我们研究的局限性。使用基于人群的数据进行流行病学调查对于更好地了解这种疾病很重要。
