Hodgson Nicole C
Department of Surgery, McMaster University, Juravinski Regional Cancer Center, Hamilton, Ontario, Canada.
J Surg Oncol. 2005 Jan 1;89(1):1-4. doi: 10.1002/jso.20167.
The objective of this study was to define the incidence trends of Merkel cell carcinoma (MCC), a rare and aggressive cutaneous malignancy.
All cases of MCC of the skin between 1986 and 2001 were identified using the surveillance, epidemiology, and end results (SEER) program. Overall age-adjusted, gender-specific, age-specific, stage-specific, and regional incidence rates were calculated. All rates are per 100,000 and age-adjusted to the 2000 US standard population. Estimated annual percent change (EAPC) was calculated using a linear least squares model.
A total of 1,124 cases of MCC were identified in the SEER registries. The rate of MCC increased from 0.15 cases per 100,000 in 1986 to 0.44 cases per 100,000 in 2001. The EAPC for the time period was 8.08%. This was statistically significant (95% CI: 6.29, 9.90, P-value < 0.05). Age-specific incidence (5-year age groups) were highest in the elderly, 4.28 per 100,000 in the 85+ age group.
MCC incidence rates have increased threefold over the 1986-2001 period. Rates are highest in the elderly population. Further etiologic studies and identification of high-risk populations are warranted.
本研究的目的是确定默克尔细胞癌（MCC）这一罕见且侵袭性皮肤恶性肿瘤的发病趋势。
利用监测、流行病学及最终结果（SEER）项目识别1986年至2001年间所有皮肤MCC病例。计算总体年龄调整发病率、性别特异性发病率、年龄特异性发病率、分期特异性发病率和区域发病率。所有发病率均为每10万人的发病率，并根据2000年美国标准人口进行年龄调整。使用线性最小二乘法模型计算估计年变化百分比（EAPC）。
在SEER登记处共识别出1124例MCC病例。MCC发病率从1986年的每10万人0.15例增至2001年的每10万人0.44例。该时间段的EAPC为8.08%。这具有统计学意义（95%CI：6.29，9.90，P值<0.05）。年龄特异性发病率（5岁年龄组）在老年人中最高，85岁及以上年龄组为每10万人4.28例。
1986年至2001年期间，MCC发病率增长了两倍。发病率在老年人群中最高。有必要进行进一步的病因学研究并识别高危人群。
