Kraemer W J, Fragala M S, Watson G, Volek J S, Rubin M R, French D N, Maresh C M, Vingren J L, Hatfield D L, Spiering B A, Yu-Ho J, Hughes S L, Case H S, Stuempfle K J, Lehmann D R, Bailey S, Evans D S
University of Connecticut, Human Performance Laboratory, Storrs, Connecticut 06269-1110, USA.
Br J Sports Med. 2008 Feb;42(2):116-20; discussion 120. doi: 10.1136/bjsm.2007.035535. Epub 2007 Jul 17.
Severe physical and environmental stress seems to have a suppressive effect on the hypothalamic-pituitary-gonadal (HPG) axis in men. Examining hormonal responses to an extreme 160-km competition across frozen Alaska provides a unique opportunity to study this intense stress.
To examine hormonal responses to an ultra-endurance race.
Blood samples were obtained from 16 men before and after racing and analyzed for testosterone, interleukin-6 (IL-6), growth hormone (GH) and cortisol. Six subjects (mean (SD) age 42 (7) years; body mass 78.9 (7.1) kg; height 1.78 (0.05) m raced by bicycle (cyclists) and 10 subjects (age 35 (9) years; body mass 77.9 (10.6) kg; height, 1.82 (0.05) m) raced by foot (runners). Mean (SD) finish times were 21.83 (6.27) and 33.98 (6.12) h, respectively.
In cyclists there were significant (p< or =0.05) mean (SD) pre-race to post-race increases in cortisol (254.83 (135.26) to 535.99 (232.22) nmol/l), GH (0.12 (0.23) to 3.21 (3.33) microg/ml) and IL-6 (2.36 (0.42) to 10.15 (3.28) pg/ml), and a significant decrease in testosterone (13.81 (3.19) to 5.59 (3.74) nmol/l). Similarly, in runners there were significant pre-race to post-race increases in cortisol (142.09 (50.74) to 452.21 (163.40) ng/ml), GH (0.12 (0.23) to 3.21 (3.33) microg/ml) and IL-6 (2.42 (0.68) to 12.25 (1.78) pg/ml), and a significant decrease in testosterone (12.32 (4.47) to 6.96 (3.19) nmol/l). There were no significant differences in the hormonal levels between cyclists and runners (p>0.05).
These data suggest a suppression of the hypopituitary-gonadal axis potentially mediated by amplification of adrenal stress responses to such an ultra-endurance race in environmentally stressful conditions.
严重的身体和环境压力似乎会对男性的下丘脑 - 垂体 - 性腺（HPG）轴产生抑制作用。研究激素对一场穿越阿拉斯加冻土带的160公里极限比赛的反应，为研究这种强烈压力提供了一个独特的机会。
研究激素对超耐力比赛的反应。
在比赛前后从16名男性身上采集血样，分析睾酮、白细胞介素 - 6（IL - 6）、生长激素（GH）和皮质醇。6名受试者（平均（标准差）年龄42（7）岁；体重78.9（7.1）千克；身高1.78（0.05）米）骑自行车参赛（自行车运动员），10名受试者（年龄35（9）岁；体重77.9（10.6）千克；身高1.82（0.05）米）跑步参赛（跑步运动员）。平均（标准差）完赛时间分别为21.83（6.27）和33.98（6.12）小时。
自行车运动员中，从赛前到赛后，皮质醇（254.83（135.26）至535.99（232.22）nmol/L）、GH（0.12（0.23）至3.21（3.33）μg/ml）和IL - 6（2.36（0.42）至10.15（3.28）pg/ml）显著（p≤0.05）升高，睾酮显著降低（13.81（3.19）至5.59（3.74）nmol/L）。同样，跑步运动员中，从赛前到赛后，皮质醇（142.09（50.74）至452.21（163.40）ng/ml）、GH（0.12（0.23）至3.21（3.33）μg/ml）和IL - 6（2.42（0.68）至12.25（1.78）pg/ml）显著升高，睾酮显著降低（12.32（4.47）至6.96（3.19）nmol/L）。自行车运动员和跑步运动员的激素水平无显著差异（p>0.05）。
这些数据表明，在环境压力较大的情况下，这种超耐力比赛可能通过增强肾上腺应激反应，潜在地抑制垂体 - 性腺轴。
