Jäger A K, Eldeen I M S, van Staden J
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen, Denmark.
Phytother Res. 2007 Dec;21(12):1251-2. doi: 10.1002/ptr.2236.
The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase.
本研究的目的是调查临床观察到的玫瑰果治疗骨关节炎的疗效是否归因于对环氧化酶-1和-2的抑制作用。对玫瑰果的水提取物、甲醇提取物、二氯甲烷提取物和己烷提取物进行了体外环氧化酶-1和-2活性测试。有机溶剂提取物对环氧化酶-1和-2均显示出良好的抑制作用。甲醇提取物在两种检测中活性最高，对环氧化酶-1的半数抑制浓度（IC50）值为12微克/毫升，对环氧化酶-2的IC50值为19微克/毫升。临床观察到的效果可能归因于对环氧化酶的抑制作用。
