Magari K, Fukushima H, Ishimaru S, Furukawa K, Yagyu Y, Takano T
Second Department of Surgery, Tokyo Medical College, Japan.
Artif Organs. 1991 Dec;15(6):492-7.
A biomimetic prosthesis was prepared from canine arterial wall by extraction with 70% formic acid. Under these conditions, the arterial architecture consisting of elastic lamella was conserved and the tensile strength was retained. Attachment of 51Cr-endothelial cells to the surface of the prosthesis was enhanced in the presence of collagen (50 micrograms/ml), fibronectin (20 micrograms/ml), and fibrinogen (500 micrograms/ml). These agents also enhanced the adhesion of 51Cr-platelets. However, preattachment of endothelial cells to prostheses prevented platelet adhesion.
通过用70%甲酸萃取，从犬动脉壁制备了一种仿生假体。在这些条件下，由弹性薄片组成的动脉结构得以保留，并且拉伸强度也得以维持。在胶原蛋白（50微克/毫升）、纤连蛋白（20微克/毫升）和纤维蛋白原（500微克/毫升）存在的情况下，51铬标记的内皮细胞与假体表面的附着得到增强。这些物质也增强了51铬标记的血小板的黏附。然而，内皮细胞预先附着到假体上可防止血小板黏附。
