Wu Qun-Li, Liang Xiao-Chun
Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):775-8.
Traditional Chinese medicine has certain effects on diabetic peripheral neuropathy and predominates in the integral medication of multi-factorial, multi-target action, et al. In this paper, the experimental studies concerning the effects of Chinese compound recipes on diabetic peripheral neuropathy in recent 6 years are reviewed in respect of the polyalcohol pathway and related metabolic disorder, the activation of protein kinase C, the formation of advanced glycation endoproducts, oxidative stress, neurotrophy factors, haemodynamics and blood vessel factors. It analyzes the existing problems and looks into the future research in this domain as well.
中医对糖尿病周围神经病变有一定疗效，在多因素、多靶点整体用药等方面具有优势。本文就近年来6年有关中药复方对糖尿病周围神经病变影响的实验研究，从多元醇途径及相关代谢紊乱、蛋白激酶C激活、晚期糖基化终末产物形成、氧化应激、神经营养因子、血液动力学及血管因素等方面进行综述，并分析存在的问题，展望该领域未来的研究方向。
