Wang Jie, Zhang Jin-sheng
Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Zhongguo Zhong Yao Za Zhi. 2007 Jun;32(11):1005-8.
According to research results of the lipid-lowering Chinese medicine at home and abroad in recent years, the paper will elaborate on the research status of the antihyperlipidemia effects of chinese medicine from the aspects of its vitro screening model, effective monomer, compounding, single medicine and antihyperlipidemia traditional Chinese medicine patent prescription. Put the ideas of development and use on the antihyperlipidemia effects of chinese medicine effective monomer and components medicine compatibility, emphasize on through new medicine screening cell model to find the antihyperlipidemia effects of chinese medicine monomer and antihyperlipidemia mechanism, breakthrough the single mode to use the accumulate of experience in clinical research as the development of new drugs. Study against the changes of the single-ingredient fixed component, the modify of the effective components combination of different drugs, the component compatibility of the different pathological link and the properties of the effective monomer, accelerate the theoretical innovation about the combination of effective medicine monomer, improve the research levels of the medicine combination from pieces to component, make the action target, link, and mechanism of herbal pharmacology more clear, promote the new Chinese herbal research, the improvement of the clinical efficient and the theory innovation of traditional chinese medicine.
根据近年来国内外降血脂中药的研究成果,本文将从体外筛选模型、有效单体、复方、单味药及抗高血脂中药专利方剂等方面阐述中药抗高血脂作用的研究现状。提出中药有效单体及组方配伍抗高血脂作用的开发利用思路,强调通过新药筛选细胞模型寻找中药单体抗高血脂作用及机制,突破以临床研究经验积累为新药开发的单一模式。针对单味固定成分的变化、不同药物有效成分组合的修饰、不同病理环节的成分配伍及有效单体的性质等进行研究,加快有效药物单体组合的理论创新,提高中药组方从饮片到成分的研究水平,使中药药理作用靶点、环节及机制更加明确,推动中药新药研究、临床疗效提高及中医药理论创新。