Ekstrand K, Nilsson J A, Lilja B, Boström P A, Arborelius M
Department of Clinical Physiology, Lund University, Allmänna Sjukhuset, Malmö, Sweden.
Aviat Space Environ Med. 1991 Oct;62(10):963-8.
In order to discover markers for the development of cardiovascular disease and hypertension, we studied systolic and diastolic blood pressure, ECG, and heart rate before, during and after exercise; body mass index (BMI); serum cholesterol; and smoking habits in 183 male aviators (mean age 41 years at commencement, and 55 at follow-up). Those developing cardiovascular disease had an overrepresentation of smokers but the disease could not be related to any other variable. By contrast we found the following independent markers for prediction of future hypertension in normotensive aviators: increased BMI, increased diastolic blood pressure at 50 W, low heart rate at maximal exercise and smoking. Of these markers high diastolic blood pressure and low heart rate during exercise are new. Subjects with initially elevated blood pressure who did not develop hypertension decreased their diastolic blood pressure after exercise in contrast to those developing hypertension.
为了发现心血管疾病和高血压发展的标志物，我们研究了183名男性飞行员运动前、运动期间和运动后的收缩压和舒张压、心电图及心率；体重指数（BMI）；血清胆固醇；以及吸烟习惯（开始研究时平均年龄41岁，随访时55岁）。患心血管疾病的人群中吸烟者比例过高，但该疾病与任何其他变量均无关联。相比之下，我们发现了以下可预测血压正常飞行员未来患高血压的独立标志物：BMI升高、50瓦时舒张压升高、最大运动量时心率低以及吸烟。在这些标志物中，运动期间舒张压高和心率低是新发现的。与患高血压的人相比，最初血压升高但未患高血压的受试者运动后舒张压降低。
