Clarke Loren E, Seykora John T
Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
J Cutan Pathol. 2007 Aug;34(8):654-7. doi: 10.1111/j.1600-0560.2006.00671.x.
An 83-year-old Caucasian woman presented to her dermatologist with a 5-cm subcutaneous tumor on her right thigh. The lesion had been present for many years, but had recently enlarged. Incisional biopsy showed a multinodular tumor composed of variably sized glands comprised of a luminal layer of epithelial cells surrounded by one or more layers of myoepithelial cells. The histopathologic features resembled those of adenomyoepithelioma, an uncommon neoplasm usually encountered within the breast. Primary cutaneous adenomyoepithelioma is very rare yet shares histopathologic features with common cutaneous lesions such as spiradenomas and benign mixed tumors (chondroid syringomas). Primary cutaneous adenomyoepithelioma is part of the spectrum of epithelial-myoepithelial tumors that includes benign mixed tumor, myoepithelioma and myoepithelial carcinoma. This rare tumor may mimic malignant lesions including metastatic adenocarcinoma. Like its breast counterpart, primary cutaneous adenomyoepithelioma should probably be regarded as a neoplasm of borderline malignant potential.
一名83岁的白人女性因右大腿出现一个5厘米的皮下肿瘤，前往皮肤科医生处就诊。该病变已存在多年，但最近有所增大。切开活检显示为一个多结节肿瘤，由大小不一的腺体组成，这些腺体由一层管腔上皮细胞层和一层或多层肌上皮细胞围绕。组织病理学特征类似于腺肌上皮瘤，这是一种通常在乳腺中出现的罕见肿瘤。原发性皮肤腺肌上皮瘤非常罕见，但与常见的皮肤病变如汗腺螺旋瘤和良性混合瘤（软骨样汗管瘤）具有相同的组织病理学特征。原发性皮肤腺肌上皮瘤是上皮-肌上皮肿瘤谱系的一部分，该谱系包括良性混合瘤、肌上皮瘤和肌上皮癌。这种罕见肿瘤可能会模仿恶性病变，包括转移性腺癌。与其乳腺对应物一样，原发性皮肤腺肌上皮瘤可能应被视为具有潜在交界恶性的肿瘤。
